Zadiempa Duo Tablets 12.5/1000 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dose for this medication is 1 tablet, twice daily. The dosage is determined based on the current treatment regimen, efficacy, and tolerability of each patient, ensuring that the maximum recommended daily doses of empagliflozin (25 mg) and metformin (2000 mg) are not exceeded. For patients who are unable to achieve sufficient blood sugar control with metformin alone or in combination with insulin or other medications, the recommended dose is

This medication is an antidiabetic agent that helps lower blood sugar. This medication should not be used in cases of severe renal impairment or acute illness before administration. It should also not be administered to patients with type 1 diabetes or those showing symptoms of metabolic acidosis such as lactic acidosis or ketoacidosis. Dosage adjustments are necessary based on renal function, and treatment should be discontinued if renal function declines. Caution is required when taking this medication alongside insulin or sulfonylureas due to the risk of hypoglycemia. The risk of urinary tract infections or genital infections may increase, so healthcare personnel should be notified immediately if infection symptoms appear. Care should be taken to avoid dehydration or fluid loss during treatment, and if symptoms of dehydration occur, drug administration may be temporarily suspended. Patients with liver dysfunction are also advised to avoid using this medication. This medication should be discontinued before and after examinations involving iodinated contrast agents and only resumed after renal function is confirmed normal. It is safest for women who are pregnant or breastfeeding not to take this medication. Elderly patients or those with poor nutritional status are at higher risk of hypoglycemia or lactic acidosis and should be monitored carefully. This medication may decrease serum vitamin B12 levels, so regular blood tests are recommended. Overdose may lead to serious side effects such as lactic acidosis; therefore, dosages should be strictly followed, and healthcare providers should be visited immediately if unusual symptoms appear. The safety and efficacy of this medication have not been established in children, so it is not recommended for use in this age group. Common adverse reactions during treatment may include hypoglycemia, urinary tract infections, increased urination, and gastrointestinal disturbances, so healthcare personnel should be consulted if symptoms arise. Finally, it is essential to take this medication according to the prescribing physician's instructions and not to discontinuate or change the dosage arbitrarily.

Serious side effects

Hives, angioedema, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rashes with high fever, blisters, peeling skin, oral/ocular mucosal pain, severe skin reactions, difficulty breathing or shortness of breath, asthma attacks, cough with fever accompanied respiratory dysfunction, yellowing of skin or eyes (jaundice), severe systemic fatigue, liver dysfunction (jaundice), sudden and severe

Mild side effects

Nausea, vomiting, diarrhea, abdominal pain, loss of appetite, constipation, dysgeusia, itching, rash, erythema, angioedema, increased urination, urinary difficulty, thirst, serum lipid increase, elevated serum creatinine, increased hematocrit, vulvovaginal candidiasis, vulvitis, balanitis, other genital infections, hypoglycemia (when used with insulin or sulfonylureas), reduced fluid volume, headache, dizziness, insomnia, asthenia, chest discomfort, chest pain,

This medication may be sensitive to air and moisture, therefore it should be stored in a tightly sealed container. The storage temperature should be kept between 1 to 30 degrees Celsius at room temperature. Proper storage will help maintain the medication's effectiveness and safety for an extended period.

Appearance

Bilateral convex oval film-coated tablets with a dark brownish purple color

Package unit

60 tablets/box (10 tablets/PTP x 6), 10 tablets/box (10 tablets/PTP x 1), 60 tablets/bottle, 30 tablets/bottle