Jabia M Tablet 50/500 mg (Sitagliptin Hydrochloride Hydrate, Metformin Hydrochloride)

Adult dose

This medication is generally taken twice daily with food, and the dosage should be gradually increased to reduce gastrointestinal side effects from metformin. 1. Patients not currently treated with metformin: Take this medication 50/500 mg twice a day, one tablet at a time, and may increase to 50/1000 mg, one tablet twice a day. 2. Patients receiving metformin treatment:

This medication contains both sitagliptin and metformin, which help regulate blood sugar levels. First, sitagliptin may rarely cause allergic reactions, so if symptoms such as skin rash or difficulty breathing occur, it should be discontinued immediately. Additionally, there is a risk of acute pancreatitis, which is inflammation of the pancreas, so if symptoms such as abdominal pain or vomiting occur, careful observation is necessary. Metformin can cause a rare side effect known as severe lactic acidosis, which occurs when lactic acid accumulates excessively in the body, leading to a dangerous condition; symptoms include muscle pain, weakness, and difficulty breathing. If these symptoms appear, consult a doctor immediately, and it should not be administered to patients with impaired kidney function. This medication should not be used in patients with moderately to severely impaired kidney function, those with acute heart disease, patients with severely compromised liver function, or women who are pregnant or breastfeeding. During use, it is important to avoid irregular meals or intense exercise, and caution should be exercised regarding blood sugar changes if taken with other medications. Also, hypoglycemia may occur; therefore, especially when taking it concurrently with insulin or sulfonylureas, blood sugar levels should be checked frequently and symptoms should be monitored. While taking this medication, regular kidney function and blood tests should be conducted, and since vitamin B12 levels may decrease, supplementation may be necessary. Consumption of alcohol should be avoided, especially in conditions of impaired liver function, as the risk of lactic acidosis increases. If surgery is planned, the medication should be temporarily stopped 48 hours before the surgery and resumed only after kidney function is confirmed to be normal post-surgery. If blisters appear on the skin or severe joint pain occurs, notify a doctor immediately and stop taking this medication. Lastly, this medication should not be used in individuals under 18 years or in pregnant or nursing women due to lack of established safety.

Serious side effects

Hives, severe swelling (angioedema), rash, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash with fever, blisters, skin peeling, pain in mouth/eye mucous membranes, severe skin adverse reactions, asthma attacks, respiratory difficulties accompanied by cough and fever, jaundice (yellowing of the skin or eyes), generalized weakness, liver abnormalities (jaundice), sudden and very severe headache.

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is important to maintain a storage temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the drug's effectiveness and safety.

Appearance

Bright pink oval film-coated tablet

Package unit

60 tablets/box [10T/PTP*6]