Januese Tablet 100 mg (Sitagliptin Hydrochloride Hydrate)

Adult dosage

This medication is administered once daily at a dose of 100 mg either as monotherapy or in combination with other drugs, with a maximum dose of 100 mg per day. It can be taken regardless of meals. Dosage adjustment for patients with renal impairment: 1. Mildly impaired renal function (eGFR ≥ 60 and < 90) does not require dosage adjustment. 2. Moderately impaired renal function (eGFR ≥ 45 and < 60) does not require dosage adjustment.

Severe allergic reactions may occur during the use of this medication, so if symptoms such as skin rash or difficulty breathing arise, you should immediately stop taking the drug and consult a doctor. Additionally, serious pancreatic inflammation known as pancreatitis may occur, so if symptoms like abdominal pain, vomiting, or fever occur, you should inform medical personnel immediately. Patients with type 1 diabetes or diabetic ketoacidosis should not use this medication, nor should it be administered to those allergic to the drug or its components. Patients with impaired renal function should have their dosage adjusted, and regular kidney function tests should be conducted under a doctor's guidance. Hypoglycemia may occur while taking this medication, especially when taken alongside blood sugar-lowering agents such as insulin or sulfonylureas, so careful observation of hypoglycemic symptoms is necessary. If symptoms such as severe joint pain or the formation of blisters on the skin occur, inform a doctor immediately, and discontinue the medication if necessary. Pregnant or breastfeeding women are advised to avoid using this medication, and its safety and efficacy have not been established for children under 18 years old. Elderly patients may experience decreased kidney function, so it is important to regularly check kidney function before and during treatment with this medication. In the case of overdose, immediate medical attention should be sought for appropriate treatment, and some drugs may be removed through hemodialysis, depending on medical staff’s judgment.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, rash, severe skin reactions (including Stevens-Johnson syndrome, exfoliative skin disease), acute pancreatitis, severe hypoglycemia (including altered consciousness, seizures), severe and debilitating joint pain, bullous pemphigoid, acute renal failure, liver abnormalities (elevated liver enzymes, possibility of jaundice), severe allergic reactions, extreme swelling, increased blood pressure, pneumonia, complications of diabetes, metabolic acidosis

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• diarrhea
• nausea
• abdominal pain
• constipation
• vomiting
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air exposure, and the storage temperature should be maintained at room temperature between 1 to 30 degrees Celsius. Proper storage can help retain the drug's efficacy over time.

Appearance

Orange, round, biconvex film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP x 3]