Dapael Duo Sustained-Release Tablets 10/500 mg

Adult dose

This medication is generally administered once daily with dinner. The maximum dose is dapagliflozin 10 mg/metformin sustained-release 2000 mg once daily, with 2 tablets of 5 mg/1000 mg. When used as initial therapy, the recommended starting dose is one tablet of either 5 mg/500 mg or 10 mg/500 mg once daily. To reduce gastrointestinal side effects of metformin, the dosage should be adjusted gradually. This

This medication is used in the treatment of type 2 diabetes to help control blood sugar levels. It can rarely cause a dangerous condition known as lactic acidosis, so patients with poor kidney function, severe infections, dehydration, or cardiovascular issues should not use it. In addition, when used with insulin or other diabetes medications, there is a risk of hypoglycemia, so caution is necessary. Patients with impaired kidney function or the elderly should use this medication cautiously, and kidney function and fluid status should be frequently monitored before and during use. Women who are pregnant or breastfeeding should not take this medication, and its safety in children has not been established. This medication may increase the risk of genital and urinary tract infections, so if symptoms of infection occur, patients should consult a doctor immediately. Signs of decreased fluid volume or low blood pressure may occur, so it is important to periodically check blood pressure and fluid status. Vitamin B12 deficiency may develop, so it is advisable to check blood vitamin B12 levels during prolonged use. Excessive alcohol consumption should be avoided while taking this medication, and if undergoing surgery or imaging tests, it should be discontinued for a certain period. Also, this medication may interact with other drugs, so if taking other medications, it is essential to inform the doctor or pharmacist. In case of overdose, seek medical attention immediately, and this medication should be kept out of the reach of children. There may be symptoms like dizziness when driving or operating machinery, so caution is advised.

Serious side effects

Lactic acidosis, severe hypoglycemia, severe allergic reactions, severe skin reactions, respiratory issues, liver abnormalities (jaundice), severe neurological symptoms, severe edema or urination abnormalities, diabetic ketoacidosis, urinary sepsis and pyelonephritis, acute kidney injury and renal dysfunction, Guillain-Barré syndrome, bacterial pneumonia, sialadenitis, atrial fibrillation, acute cholecystitis, perineal necrosis

Mild side effects

• Hypoglycemia
• vulvitis
• balanitis and related genital infections
• urinary tract infections
• fungal infections
• decreased fluid volume
• thirst
• dizziness
• constipation
• dry mouth

This medication should be stored in a tightly sealed container to prevent air or moisture ingress. It is best to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Pink, double convex, oval-shaped sustained-release film-coated tablets

Package unit

30 tablets/box [(6 tablets/PTP)*5], 30 tablets/bottle, 200 tablets/bottle