Dapaijisoseobangjeong 10/500 mg (Dapagliflozin, Metformin)

Adult dose

Typically, this medication is administered once daily with the evening meal. The maximum dosage is 10 mg of dapagliflozin/2000 mg of extended-release metformin once daily and 2 tablets of 5 mg/1000 mg. The recommended starting dosage when used as an initial therapy is 1 tablet of 5 mg/500 mg or 10 mg/500 mg once daily. Dosage adjustments should be made gradually to reduce gastrointestinal side effects of metformin.

This medication contains two active ingredients for the treatment of diabetes. First, this medication works by preventing the reabsorption of glucose in the kidneys, thus helping to lower blood sugar by excreting glucose in the urine. However, there are several precautions to be aware of when using this medication. First, this medication can rarely cause a serious metabolic disorder called lactic acidosis. This condition can lead to excessive buildup of lactic acid in the body, which can be dangerous; thus, if symptoms such as shortness of breath, muscle pain, fatigue, or abdominal pain occur, consult a doctor immediately. Second, when used with other diabetes medications or insulin, hypoglycemia may occur, so careful monitoring of blood sugar changes is necessary. Third, it is safer not to use this medication in patients with poor kidney function or conditions such as dehydration, severe infection, heart problems, or liver dysfunction. Fourth, women who are pregnant or breastfeeding should not take this medication, and if planning to become pregnant, they should consult their doctor. Fifth, this medication can increase urine volume leading to fluid depletion; therefore, patients with dehydration symptoms or low blood pressure should be cautious. Sixth, this medication can increase the risk of genital and urinary tract infections; if symptoms of infection occur, adequate treatment should be sought. Seventh, vitamin B12 levels may decrease, so regular blood tests are recommended for long-term use. Eighth, alcohol consumption may increase the risk of side effects from this medication, so excessive drinking should be avoided. Ninth, if undergoing surgery or testing that involves iodine contrast while taking this medication, it may be necessary to pause taking the medication and check kidney function for a period of time. Lastly, this medication may cause dizziness or symptoms of dehydration; thus, caution is needed when driving or operating machinery. This medication should be taken strictly according to a doctor's prescription and instructions, and any unusual symptoms should be reported to healthcare professionals immediately.

Serious side effects

• Lactic acidosis
• severe hypoglycemia
• severe edema
• diabetic ketoacidosis
• urosepsis
• pyelonephritis
• acute kidney injury
• renal dysfunction
• rash
• severe skin reactions

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, hypoglycemia, decreased fluid volume, polydipsia, dizziness, constipation, dry mouth, lower back pain, dysuria, polyuria, nocturia, genital itching, increased hematocrit, reduced creatinine clearance at the initiation of treatment, dyslipidemia, elevated blood creatinine, elevated blood urea, weight loss, diarrhea, nausea/vomiting, decreased vitamin B12, abdominal pain, dyspepsia, abdominal bloating

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. It is important to maintain a storage temperature between 1 and 30 degrees Celsius to preserve the effectiveness and safety of the medication.

Appearance

Pink, oval-shaped extended-release film-coated tablet with both sides convex

Package unit

30 tablets/box [(6 tablets/PTP)*5], 30 tablets/bottle, 200 tablets/bottle