Posigledio Extended Release Tablet 10/500 mg

Adult dose

This medication is generally administered once daily with dinner. The maximum dose is dapagliflozin 10mg extended-release metformin 2000mg once daily, administered in two tablets of 5mg/1000mg. Recommended starting dosage when used as initial therapy is one tablet of 5mg/500mg or 10mg/500mg once daily. To minimize gastrointestinal side effects of metformin, the dosage should be adjusted gradually.

This medication helps control blood sugar levels. However, it can rarely cause a serious condition known as lactic acidosis; hence, it should not be used in patients with poor kidney function or severe infections or dehydration. Additionally, caution is needed when used with insulin or other diabetes medications, as there is a risk of hypoglycemia. It should not be administered to patients with moderate to severe renal impairment, liver dysfunction, or to women who are pregnant or breastfeeding. This medication should be temporarily discontinued before surgery or examinations using iodine contrast agents, and resumed only after kidney function has been confirmed as normal. Use in elderly patients or those with reduced fluid volume or at risk of low blood pressure should be done cautiously, with periodic monitoring of blood pressure and kidney function. During treatment with this medication, genital infections or urinary tract infections may occur, and should be promptly treated upon symptom onset. Additionally, vitamin B12 deficiency may occur, so routine blood tests are recommended to monitor levels. Excessive alcohol consumption can increase the risk of side effects of this medication, so it should be avoided. This medication is contraindicated during pregnancy, and should be discontinued immediately upon confirmation of pregnancy. The use in children or elderly patients over 80 years is not recommended, and kidney function must be checked in elderly patients. In case of overdose, it is imperative to seek medical attention immediately. Lastly, this medication should be kept out of reach of children and stored in its original container.

Serious side effects

• Severe lactic acidosis
• severe hypoglycemia
• acute renal failure
• severe infections
• cardiovascular collapse
• acute myocardial infarction
• sepsis
• severe allergic reactions
• severe skin reactions
• respiratory problems

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infection, fungal infection, hypoglycemia (when used with sulfonylurea or insulin), reduced fluid volume, dry mouth, dizziness, constipation, back pain, painful urination, polyuria, nocturia, vulvar itching, genital itching, elevated hematocrit, decreased initial renal creatinine clearance, dyslipidemia, elevated serum creatinine early in treatment, increased blood urea

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture. It is important to maintain storage temperature between 1 and 30 degrees Celsius.

Appearance

Pink, double-sided convex oval shaped extended-release film-coated tablet

Package unit

30 tablets/box [(6 tablets/PTP)*5], 30 tablets/bottle, 200 tablets/bottle