Sitasingle 25 mg (Sitagliptin Hydrochloride Hydrate)

Adult dosage

The usual dose is 100 mg once daily either as monotherapy or as part of combination therapy, with a maximum daily dosage of 100 mg. This medication can be taken regardless of meals. In patients with renal impairment, dosage adjustments are necessary based on renal function. - Mild renal impairment (glomerular filtration rate 60-90 mL/min/1.73 m2): No dosage adjustment needed. - Moderate renal impairment (glomerular filtration rate 45-60 mL/min/1.73 m2): Dosage adjustment may be necessary.

This medication may cause hypersensitivity reactions; if allergic symptoms occur, use should be discontinued immediately, and a doctor's consultation is required. Serious allergic reactions such as anaphylaxis, angioedema, and severe skin disorders have been reported, so caution is needed. If symptoms of acute pancreatitis occur during treatment, medical personnel should be notified immediately, and if pancreatitis is suspected, drug use should be suspended. Patients with type 1 diabetes or diabetic ketoacidosis should not use this medication. Patients with impaired renal function need dosage adjustments, therefore, they should take the medication according to the doctor’s instructions. Hypoglycemia may occur with this medication, whether used alone or with other diabetes treatments, so blood glucose levels should be monitored regularly. Caution is especially needed when combined with insulin or sulfonylureas due to an increased risk of hypoglycemia. Symptoms such as headache, upper respiratory tract infection, nasopharyngitis, diarrhea, nausea, and others may occur; if symptoms persist, consultation with medical personnel is advised. Severe joint pain may occur, and if worsening joint pain symptoms arise, discontinuation of the medication and a doctor's consultation should be sought. If skin conditions like bullous pemphigoid occur, medication should be discontinued immediately, and a consultation with a dermatologist is required. The use of this medication is not recommended during pregnancy or breastfeeding, and safety and efficacy in children under 18 years have not been established. Elderly patients may have reduced renal function, so renal function should be assessed prior to administration, and dosage adjustments might be necessary. In case of overdose, medical attention should be sought immediately, as this medication can be partially removed by hemodialysis. While interactions with other medications are relatively minimal, caution is needed when used in combination with specific drugs, so it is essential to inform medical personnel about any ongoing medications.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reactions), severe rash accompanied by high fever, blisters, skin peeling, oral/ocular mucosal pain (severe skin adverse reactions), jaundice (yellowing of skin or eyes), profound fatigue (liver abnormalities), sudden and very severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis (serious neurological adverse reactions).

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• diarrhea
• nausea
• constipation
• myalgia
• limb pain
• back pain
• pruritus

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius. This way, the effectiveness of the medication can be preserved for a long time.

Appearance

Bright yellow-orange round film-coated tablet

Package unit

Bottle packaging - 100 tablets/bottle, bottle packaging - 30 tablets/bottle