Dapasitin Tablet 10/100 mg (Dapagliflozin, Sitagliptin)

Adult dosage

For patients taking sitagliptin 100 mg and dapagliflozin 10 mg, the recommended dose is one tablet daily regardless of meals. The tablet should be swallowed whole.

This medication contains sitagliptin and dapagliflozin and is used for diabetes treatment. Firstly, the sitagliptin ingredient may cause rare but serious allergic reactions; thus, patients should seek immediate medical attention if symptoms such as skin rash, difficulty breathing, or swelling of the face or lips occur within three months of administration. Moreover, sitagliptin may cause acute pancreatitis, and if symptoms like abdominal pain, nausea, or vomiting arise, patients should stop taking the medication immediately and consult a doctor. This medication is not to be administered to patients who are allergic to the main ingredients or excipients, patients with type 1 diabetes, diabetic ketoacidosis patients, those on dialysis, and specific genetic lactose-intolerant patients. Dapagliflozin may cause hypotension or kidney impairment in patients with decreased body fluid volume or poor kidney function, so these patients must have their kidney function and fluid status thoroughly assessed before administration and monitored closely during treatment. Sitagliptin is excreted through the kidneys, thus requiring dose adjustment in patients with impaired kidney function. Patients with an allergy to the yellow dye No. 5 included in this medication should use it with caution. While taking this medication, symptoms such as genital infections, urinary tract infections, hypoglycemia, dehydration symptoms, and ketoacidosis may occur, so patients should inform medical personnel immediately if any such symptoms arise. In particular, dapagliflozin may have a weight-reducing effect in patients with poorly controlled blood glucose. Rare cases of severe infections around the genitals (perineal necrotizing fasciitis) have been reported in diabetic patients, and if symptoms such as fever, pain, or swelling appear, immediate treatment is necessary. Pregnant or breastfeeding women are advised not to use this medication. Elderly patients or those with decreased kidney function should evaluate their kidney function before treatment and should regularly monitor their kidney status during treatment. This medication may increase the risk of hypoglycemia when used with other glucose-lowering agents, requiring dose adjustments of insulin or sulfonylureas. In case of overdose, immediate consultation with medical personnel and appropriate treatment should be sought; dialysis removal is limited. Lastly, the safety and efficacy of this medication have not been confirmed for children; thus it should not be used in patients under 18 years of age. Patients should be cautious of hypoglycemic symptoms while driving or operating machinery.

Serious side effects

• Anaphylaxis
• angioedema
• Stevens-Johnson syndrome
• exfoliative skin disorders
• acute pancreatitis
• hemorrhagic pancreatitis
• necrotizing pancreatitis
• severe allergic reactions
• severe skin adverse reactions
• difficulty breathing

Mild side effects

• Vulvovaginitis
• balanitis
• genital infections
• urinary tract infections
• fungal infections
• hypoglycemia
• dry mouth
• constipation
• back pain
• dysuria

This medication should be stored in a tightly sealed container to protect it from air and moisture, and the storage temperature should be maintained between 1 and 30 degrees Celsius at room temperature. In other words, avoid storing it in overly hot or cold places; keeping it at a stable temperature will preserve its effectiveness well.

Appearance

Yellow circular film-coated tablet

Package unit

For oral use - 28 tablets/PTP