Dapagliflozin Propanediol Hydrate / Sitagliptin Phosphate Hydrate / Metformin Hydrochloride Extended-release Tablet 10/100/1000 mg

Adult dose

To reduce gastrointestinal adverse reactions caused by metformin hydrochloride, this medication is taken once daily with the evening meal. Patients taking this 10/100/1000 mg extended-release tablet should take one tablet once daily. Patients taking the 5/50/500 mg, 5/50/750 mg, and 5/50/1000 mg extended-release tablets should take two tablets once daily. Metformin hydrochloride

This medication is a combination product containing sitagliptin, dapagliflozin, and metformin, each of which has specific precautions. First, sitagliptin can rarely cause serious allergic reactions, including anaphylaxis, angioedema, and severe skin disorders. If such symptoms occur, stop taking the medication immediately and seek medical attention. Additionally, sitagliptin can lead to acute pancreatitis, so if abdominal pain or vomiting, which are signs of pancreatitis, appears during treatment, discontinue use and visit a hospital immediately. Next, dapagliflozin may cause decreased body fluids and low blood pressure, so patients with impaired kidney function, elderly patients, or those taking diuretics should regularly monitor their blood pressure and kidney function before and during use. This medication may increase the risk of urinary tract infections and genital infections, so appropriate treatment should be obtained if any infection symptoms appear. Patients with a history of infections should exercise additional caution. Moreover, dapagliflozin can lead to diabetic ketoacidosis, even when blood sugar levels are not significantly elevated, so if symptoms such as vomiting, abdominal pain, or difficulty breathing occur, consult healthcare professionals immediately. Patients with severely impaired kidney function, acute or chronic metabolic acidosis, serious infections, or congestive heart failure should not take this medication. Metformin can rarely cause severe lactic acidosis, which can be life-threatening; therefore, patients with reduced kidney function or those at risk due to cardiopulmonary disease or sepsis should avoid taking it. Gastrointestinal side effects (nausea, vomiting, diarrhea, etc.) are common with metformin, and vitamin B12 deficiency can occur, so regular blood testing is recommended. During the course of this medication, irregular meals, excessive exercise, the use of other hypoglycemic agents, and excessive alcohol intake can increase the risk of hypoglycemia, so caution is advised. Patients scheduled to undergo a radiographic iodine contrast procedure should discontinue the use of this medication for a specified period before and after the test and avoid re-administration until kidney function has recovered. Pregnant patients, patients with impaired liver function, and patients with severe infections or cardiovascular collapse should use this medication with caution. Finally, if skin rashes, severe joint pain, blistering skin disorders, pain or swelling around the perineum occur during the use of this medication, consult a physician immediately and discontinue use if necessary.

Serious side effects

Urticaria, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rashes with high fever, blisters, skin shedding, mucosal pain in the mouth/eyes, severe skin abnormalities, shortness of breath or difficulty breathing, asthma attack, coughing with fever and respiratory abnormalities, jaundice (yellowing of skin or eyes), extreme lethargy, liver abnormalities (jaundice), sudden and very severe

Mild side effects

• Itching
• urticaria
• cold sweat
• hypoglycemia
• dizziness
• thirst
• constipation
• vomiting
• headache
• weight loss

This medication must be stored in a tightly closed container to prevent exposure to air and moisture. The appropriate storage temperature is room temperature between 1 to 30 degrees Celsius, and it should be kept away from extremely hot or cold places.

Appearance

Extended-release film-coated tablet, oval shape, double convex, with a deep yellow color

Package unit

30 tablets/bottle