Femazair Tablets 13.5 mg (Femicatinib)

Adult dose

Administer 13.5 mg of this drug orally once daily for 14 days followed by a 7-day break. It should be taken preferably at the same time each day and swallowed whole. It can be taken regardless of meals. In patients taking strong CYP3A4 inhibitors, those on 13.5 mg once daily should reduce to 9 mg once daily, and those on 9 mg once daily should reduce to 4.5 mg once daily.

This drug may be harmful to the fetus during pregnancy, so women who are pregnant or may become pregnant should not use it. Female patients of childbearing age must use effective contraception during and for one week after taking this drug, and male patients must also practice contraception during the same period to prevent their partner from becoming pregnant. It is contraindicated to take this drug if there is a hypersensitivity reaction to it or in conjunction with the herbal remedy St. John's Wort. This drug can affect phosphate levels in the blood, which could lead to hyperphosphatemia or hypophosphatemia, so phosphate levels should be regularly monitored through blood tests. It can also affect eye health, causing a condition called serous retinal detachment; therefore, regular eye examinations should be conducted before and during treatment, and if symptoms such as blurred vision or light scattering arise, a doctor should be consulted immediately. This medication can cause various side effects, with common symptoms including diarrhea, nausea, vomiting, hair loss, fatigue, dry skin, and inflammation in the mouth. In severe cases, abnormalities in liver function, reduction in kidney function, infections, and blood disorders may occur, so any abnormities should be reported to healthcare professionals immediately. This drug may interact with certain medications, so it is crucial to inform healthcare providers of any other medications being taken, especially when combined with strong CYP3A4 inhibitors or inducers or proton pump inhibitors. While taking this drug, it is advisable to avoid grapefruit or grapefruit juice, and dosage adjustments may be made as necessary to control drug concentration and effects. This medication may impair driving or operating machinery, so caution is advised while taking it. The safety and efficacy in children or patients under 18 years of age have not been established, and elderly patients take the same dosage as adults. Store this drug in its original packaging away from direct sunlight and keep it out of reach of children, and do not use expired medication.

Serious side effects

• Abdominal pain
• fever
• cholangitis
• pleural effusion
• acute kidney failure
• infectious cholangitis
• growth retardation
• hypercalcemia
• hyponatremia
• small bowel obstruction

Mild side effects

• Hyperphosphatemia
• hypophosphatemia
• hypercalcemia
• dehydration
• hair loss
• nail toxicity
• dry skin
• palmoplantar erythrodysesthesia syndrome
• diarrhea
• nausea

This medication should be stored in a tightly sealed container to protect it from air and moisture, at room temperature between 1 to 30 degrees Celsius. Storing it this way will help maintain the effectiveness of the drug for a long time.

Appearance

White to light yellow round tablets engraved on one side with "I" and on the other side with "13.5".

Package unit

14 tablets/box [14 PTX x 1]