Sitagliptin and Metformin Duo Tablet 50/1000 mg

Adult dose

This medication is generally taken twice daily with food and the dosage is gradually increased to minimize gastrointestinal side effects caused by metformin. 1. For patients not currently receiving metformin: - Initial dosage is 50/500 mg twice daily, taking 1 tablet per dose. - With dosage increase, 50/1000 mg twice daily, taking 1 tablet per dose. 2. For patients who are on metformin therapy: - Recommended initial dosage is

This medication contains two components, each with specific precautions to consider. First, one of its components can rarely cause severe allergic reactions. Such reactions may appear within 3 months after starting the medication, and if symptoms like skin rashes or breathing difficulties occur, usage should be stopped immediately, and a doctor should be consulted. Second, this medication can induce pancreatitis, an inflammation of the pancreas. Symptoms such as abdominal pain, vomiting, or fever must be reported to a doctor promptly. Third, the other component should not be administered to patients with renal impairment, severe infections, or dehydration. Additionally, patients with acute myocardial infarction, heart failure, or those who are pregnant or breastfeeding should not take this medication. Fourth, this medication may cause lactic acidosis, a rare but life-threatening metabolic complication, so patients with kidney or liver issues must consult their doctor before taking it. Fifth, during treatment, regular kidney function and blood tests should be conducted, and vitamin B12 levels should be periodically checked as deficiencies may occur. Sixth, this medication may cause hypoglycemia, so it is essential to monitor blood sugar levels regularly, especially when taken with other hypoglycemic drugs or insulin, and to take prompt action if hypoglycemic symptoms arise. Seventh, this medication should be temporarily discontinued before and after surgery or prior to tests using iodinated contrast agents, and should only be resumed once kidney function is confirmed to be normal. Eighth, alcohol consumption may increase the risk of side effects related to this medication, so it is advisable to avoid drinking while on it. Ninth, elderly patients or those with poor nutritional status are at higher risk for hypoglycemia and lactic acidosis, thereby requiring extra caution and regular health check-ups. Lastly, if unusual symptoms or discomfort occurs during treatment with this medication, it is crucial to consult healthcare professionals for appropriate measures.

Serious side effects

• Hives
• severe swelling (angioedema)
• anaphylaxis
• rash
• Stevens-Johnson syndrome
• exfoliative dermatitis
• acute pancreatitis
• acute renal failure
• dyspnea
• unstable angina

Mild side effects

Diarrhea, nausea, vomiting, abdominal pain, upper respiratory infection, nasopharyngitis, headache, weakness, pruritus, thrombocytopenia, myalgia, limb pain, back pain, itching, dizziness, reduced appetite, weight loss, constipation, hypoglycemia, and joint pain accompanied by severe and disabling effects.

This medication should be stored in a tightly sealed container to prevent air penetration and should be kept at room temperature between 1°C and 30°C. Proper storage will help maintain the medication's efficacy and safety.

Appearance

Brownish-red oval film-coated tablet

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle