Janudim Extended-Release Tablets 50/500 mg

Adult dose

Take one extended-release tablet of this medication 100/1000 mg once daily. Patients taking this medication 50/500 mg extended-release tablets or 50/1000 mg extended-release tablets should take two tablets together once daily. For patients not currently being treated with metformin: The initial total daily dosage is 100 mg of sitagliptin and 1000 mg of metformin. If sufficient blood sugar control is not achieved with the initial dosage, the dosage may be gradually increased.

This medication contains sitagliptin and metformin, which are used for diabetes treatment. First, the sitagliptin component may, although rarely, cause serious allergic reactions. Such reactions may include skin rash, hives, difficulty breathing, and severe swelling, which can appear within three months of starting treatment, so caution is advised. Additionally, sitagliptin may potentially cause pancreatitis, an inflammation of the pancreas, therefore, if symptoms such as abdominal pain, vomiting, or severe abdominal discomfort occur, consult a physician immediately. The metformin component can cause lactic acidosis, a rare but serious side effect where lactic acid builds up in the body, indicating that if symptoms such as muscle pain, difficulty breathing, fatigue, or abdominal pain occur, one should stop taking the medication and seek medical attention. This medication should not be used in patients with severe kidney impairment, acute heart failure or myocardial infarction, liver impairment, pregnant or breastfeeding women, and those with specific allergies. During treatment, kidney function should be tested regularly, and if there are conditions such as dehydration or severe infections, the medication should be temporarily discontinued. Furthermore, this medication can cause hypoglycemia, so extra caution is necessary when meals are skipped, exercise is suddenly increased, or when taken with other blood sugar-lowering agents. The medication includes color additives, so patients with allergies to specific dyes should use it cautiously. It is advisable to temporarily stop the medication before and after surgery, and to restart it only after confirming that kidney function is normal following the surgery. Common side effects that may occur during treatment include diarrhea, headache, upper respiratory infections, etc., while rare side effects may include severe joint pain, skin conditions, and muscle pain. Finally, the risk of lactic acidosis can be increased due to alcohol consumption or excessive alcohol intake, thus it is recommended to avoid drinking during treatment with this medication. The safety and efficacy of this medication have not been established in children, and in the elderly, it is necessary to adjust the dosage considering potential declines in kidney function and to conduct regular tests.

Serious side effects

• Hives, severe swelling (edema), anaphylaxis, angioedema, rash, exfoliative skin diseases (including Stevens-Johnson syndrome), severe allergic reactions
• Acute pancreatitis (including fatal/non-fatal hemorrhagic or necrotizing pancreatitis)
• Acute kidney failure (worsening renal function)
• Severe and disabling joint pain
• Bullous pemphigoid
• Elevation of liver enzymes, liver abnormalities (risk of jaundice)
• Severe lactic acidosis
• Severe edema or urination abnormalities
• Severe allergic reactions

Mild side effects

Diarrhea, upper respiratory infection, headache, nausea, vomiting, abdominal pain, nasopharyngitis, constipation, muscle pain, limb pain, back pain, pruritus, thrombocytopenia, rhabdomyolysis, hypoglycemia, the phenomenon of finding the drug in the stool

This medication is sensitive to air and moisture, hence it should be stored in a tightly sealed container. Avoid extremely hot or cold locations, and it is recommended to store it at room temperature between 1 and 30 degrees Celsius.

Appearance

Light blue, biconvex, oval-shaped extended-release film-coated tablets

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle