Janudiem Extended-Release Tablet 100/1000 mg

Adult dose

For the medication 100/1000 mg extended-release tablet, take one tablet once daily. For patients taking the 50/500 mg extended-release tablet or 50/1000 mg extended-release tablet, take two tablets simultaneously once daily. 1. For patients who are not currently being treated with metformin: - The initial dose is a total of 100 mg of sitagliptin and 1000 mg of metformin daily. - If the initial dose is not sufficient.

This medication contains both sitagliptin and metformin, used in the treatment of diabetes. First, the sitagliptin component can cause rare but serious allergic reactions; if symptoms like rash, hives, or shortness of breath occur, stop taking the medication immediately and consult a doctor. Acute pancreatitis may also occur, thus if symptoms such as abdominal pain, nausea, or vomiting arise, immediate medical attention is required. The metformin component can cause a rare side effect known as lactic acidosis, which is very dangerous; if symptoms such as difficulty breathing, muscle pain, or extreme fatigue appear, seek treatment immediately. This medication should not be administered to patients with moderate to severe renal impairment, acute heart failure, or those with severe infections or dehydration. Prior to and after examinations using iodine-based contrast materials, the intake of this medication should be temporarily suspended, and intake should resume only after confirming that renal function is normal. It is considered safe not to use this medication in pregnant or breastfeeding women and in children under 18 years of age. While taking this medication, it is essential to regularly check not only blood sugar levels but also renal function and blood test results, as a deficiency in Vitamin B12 may occur, necessitating periodic testing. Excessive alcohol consumption should be avoided during treatment, as acute or chronic alcohol intake may increase the risk of lactic acidosis. There is also a risk of hypoglycemia, so caution is needed when skipping meals or engaging in intense exercise, and when used in combination with other blood sugar-lowering agents, particularly be cautious of symptoms of hypoglycemia. Before surgery, the use of this medication should be paused for a period, and after surgery, it should only be resumed once oral intake has returned to normal and renal function has improved. Lastly, this medication may cause gastrointestinal disturbances (diarrhea, nausea, vomiting, etc.), headaches, and cold-like symptoms; if these symptoms persist, consult a physician.

Serious side effects

• Hives
• severe swelling (angioedema)
• anaphylaxis
• rash
• vasculitis
• Stevens-Johnson syndrome
• exfoliative skin disease
• hemoglobin abnormalities
• acute pancreatitis
• acute renal failure

Mild side effects

Diarrhea, upper respiratory infection, headache, nausea, vomiting, abdominal pain, constipation, nasopharyngitis, myalgia, limb pain, back pain, pruritus, hypoglycemia without severe or disabling symptoms, thrombocytopenia, rhabdomyolysis

This medication is sensitive to air and moisture, thus it should be stored in a sealed container. Additionally, it is important to store this medication at room temperature between 1 and 30 degrees Celsius to maintain its efficacy.

Appearance

Bright blue, double convex, oval-shaped extended-release film-coated tablets

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle