Janugluem XR Extended-Release Tablet 50/1000 mg

Adult dose

This drug 100/1000 mg extended-release tablet is taken once daily, 1 tablet per dose. Patients taking this drug 50/500 mg extended-release tablet or 50/1000 mg extended-release tablet take 2 tablets at once, once daily. 1. For patients not currently treated with metformin: The initial dosage is a total of sitagliptin 100 mg and metformin 1000 mg per day. If sufficient blood control cannot be achieved with the initial dose, further titration may be required.

This drug is a combination product containing sitagliptin and metformin, used for the treatment of type 2 diabetes. Firstly, sitagliptin can rarely cause severe allergic reactions, such as anaphylaxis, angioedema, and serious skin diseases, so if such symptoms occur, the medication should be stopped immediately. Also, there may be a risk of acute pancreatitis, so if symptoms such as abdominal pain or vomiting occur after taking the medication, consult a healthcare professional immediately. Metformin can cause lactic acidosis, a rare but serious metabolic complication, particularly at risk in patients with impaired kidney function or liver dysfunction. Thus, patients with moderate or worse kidney impairment, severe infections or dehydration, and heart failure should not use this drug. This drug is not recommended for use in pregnant or breastfeeding women, or in children under 18 years of age. During treatment, regular meals and exercise are important, and attention should be paid to symptoms of hypoglycemia. In particular, when taken with insulin or sulfonylureas, the risk of hypoglycemia may increase, so blood glucose should be monitored frequently, and drug dosage adjustments may be necessary. Additionally, alcohol consumption should be avoided while taking this drug, and prior to undergoing surgery or imaging tests with contrast agents, healthcare professionals should be informed to temporarily discontinue the medication. Patients should have regular kidney function tests and consult healthcare professionals immediately if any unusual symptoms occur. Finally, this drug may rarely cause side effects such as joint pain, skin rash, or muscle pain, and if these symptoms persist or worsen, patients should inform their healthcare provider.

Serious side effects

Hives, angioedema, anaphylaxis, exfoliative skin diseases including Stevens-Johnson syndrome, acute pancreatitis, acute renal failure, severe and debilitating joint pain, bullous pemphigoid, thrombocytopenia, hypoglycemia, severe lactic acidosis, liver abnormalities (including the potential for jaundice due to liver dysfunction), severe neurological symptoms (confusion, seizures, etc.), severe edema, and urinary abnormalities (including acute renal failure)

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This drug should be stored in a tightly closed container and in a place that avoids moisture. A storage temperature between 1 degree and 30 degrees Celsius at room temperature is appropriate. Storing it this way helps maintain the drug's effectiveness.

Appearance

Bright green oval extended-release film-coated tablet

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle