DanuMet XR Extended-Release Tablet 50/1000 mg

Adult dose

The 100/1000 mg extended-release tablet should be taken once a day, one tablet at a time. For patients taking the 50/500 mg extended-release tablet or the 50/1000 mg extended-release tablet, two tablets should be taken simultaneously once a day. 1. Patients who are currently not treated with metformin: The initial dosage of this medication is a daily total of 100 mg of sitagliptin and 1000 mg of metformin. For the initial dosage,

This medication contains two components, sitagliptin and metformin, and is used for the treatment of type 2 diabetes. The sitagliptin component may rarely cause serious allergic reactions such as anaphylaxis, angioedema, or severe skin conditions, and if there are abnormal symptoms within the first 3 months after taking the medication, it should be stopped immediately and a doctor consulted. Additionally, sitagliptin may cause acute pancreatitis, so if symptoms such as abdominal pain or vomiting occur, immediate medical attention is needed. The metformin component can rarely cause a serious metabolic disturbance called lactic acidosis, which is more likely in patients with impaired kidney function, liver disease, dehydration, severe infections, or heart disease. Therefore, this medication should not be used in patients with moderate to severe renal impairment, acute heart failure, acute myocardial infarction, or in pregnant or breastfeeding women. While taking this medication, kidney function should be regularly tested, and if there are symptoms of dehydration, severe vomiting, or diarrhea, the doctor should be notified immediately. Moreover, this medication lowers blood sugar, so caution is necessary when taken with other blood sugar-lowering drugs as hypoglycemia may occur. Alcohol consumption may increase the risk of lactic acidosis, so it is advisable to avoid alcohol while taking this medication. It is recommended to discontinue this medication for a certain period before and after surgery, and it should be restarted only after normal kidney function is regained following surgery. The safety and efficacy of this medication have not been established in children, and elderly patients may require dose adjustments and renal function tests due to the risk of decreased kidney function. If severe joint pain or skin blisters occur during the intake, it is important to consult a doctor immediately and discontinue the medication if such symptoms appear. This medication may interact with other medications, so it is necessary to inform the doctor of any other medications being taken, especially when used with drugs that may affect kidney function.

Serious side effects

Hives, angioedema, anaphylaxis, Stevens-Johnson syndrome, acute pancreatitis, acute renal failure, bullous pemphigoid, elevated liver enzymes, severe hypoglycemia, acute worsening of kidney function, lactic acidosis, liver abnormalities (symptoms similar to jaundice not explicitly listed)

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• myalgia
• limb pain

This medication is sensitive to air and moisture, so it should be stored in a tightly closed container. The recommended storage temperature is between 1 degrees and 30 degrees Celsius at room temperature. Proper storage helps maintain the medication's effectiveness for a longer period.

Appearance

Bright green oval extended-release film-coated tablets

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle