Vancomycin Injection 1g (Vancomycin Hydrochloride)

Adult dosage

Administer 500mg (international units) as vancomycin intravenously every 6 hours or 1g (international units) every 12 hours via IV drip. Oral vancomycin hydrochloride should be taken at a total daily dosage of 500-2000mg, divided into 3-4 doses over 7-10 days. The total daily dosage should not exceed 2g. An appropriate dosage can be diluted in about 30g of water for oral administration, and the diluted solution may be administered via a nasogastric tube.

Children's dosage

Administer 10mg (international units) per kg of body weight intravenously every 6 hours for one dose. Infants should receive 10-15mg (international units) per kg body weight intravenously every 12 hours. Infants and newborns should receive an initial dose of 15mg per kg.

This medication should not be administered to patients who have previously experienced shock from this drug or who have had allergic reactions to this drug or peptide antibiotics and aminoglycoside antibiotics. In principle, it should not be used in patients with hearing impairment or those who have previously had hearing issues due to these antibiotics, but may be used very cautiously if absolutely necessary. Patients with reduced renal function should have their blood levels monitored frequently, as this drug may accumulate in the body and cause side effects. Patients with compromised liver function should be monitored closely, as this medication can further impair liver function. Elderly patients, premature infants, newborns, and those with vestibular or auditory problems should be especially cautious when using this drug. This drug can rarely cause serious allergic reactions such as shock or anaphylaxis, so patient conditions should be closely monitored during administration, and if any abnormal symptoms arise, administration should be discontinued immediately, and appropriate measures taken. Gastrointestinal side effects may include watery stools, diarrhea, nausea, vomiting, and abdominal pain. Changes such as decreased red blood cells, white blood cells, platelets, or increased eosinophils may occur during blood tests, necessitating regular blood checking. CNS side effects may include dizziness, tinnitus, and hearing loss, requiring continuous neurological status evaluations, including hearing tests. Liver function tests may show increased bilirubin, AST, ALT, and ALP, so periodic monitoring of liver health is necessary. Kidney function tests may reveal increased BUN and creatinine levels, so ongoing monitoring of renal function is essential, with dosage adjustments made as necessary. Skin reactions can include desquamative dermatitis, bullous dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and other serious skin responses, requiring close observation of skin status. Rapid infusions may cause erythema or pain in the face and torso, as well as muscle cramps, so this drug should be infused slowly over more than 60 minutes for safety. Prolonged use may lead to antibiotic resistance or antibiotic-associated colitis from Clostridium difficile, so if diarrhea, abdominal pain, or fever occurs, administration should be stopped immediately, and a doctor consulted. This drug may increase the risk of side effects when used with other medications that affect the kidneys or nervous system, so patients must disclose any concurrent medications. Women who are pregnant or breastfeeding should consult a doctor before using this drug, as it may affect the fetus or newborn; breastfeeding should be avoided or discontinued if possible during therapy. Children, particularly premature infants and newborns, should be cautiously dosed and administered, as their kidneys may not be fully developed, allowing the drug to remain in the body longer. Elderly patients often experience decreased renal function, so kidney function should be evaluated before and during administration, and the dosage may need to be reduced accordingly. In cases of overdose, acute renal failure or hearing loss may occur, requiring immediate and appropriate treatment; this drug is not easily removed by dialysis, and professional treatment is necessary. Administering this drug via intramuscular injection can damage tissue, so it must always be administered via intravenous injection. Furthermore, this drug can exhibit chemical instability when mixed with other drugs, so care is needed when making mixtures, and the state of the solution should always be verified before administration.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, rash, erythema, facial flushing, hypotension, wheezing, respiratory distress, hives, desquamative dermatitis, bullous dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), severe allergic reactions, severe skin adverse reactions, respiratory issues, liver problems (jaundice), jaundice.

Mild side effects

• Watery stools
• diarrhea
• nausea
• vomiting
• abdominal pain
• decreased red blood cells
• decreased white blood cells
• decreased platelets
• increased eosinophils
• dizziness

This medication should be stored in a sealed container to prevent air or moisture from entering, ideally at room temperature between 1 and 30 degrees Celsius. Proper storage will maintain the drug's effectiveness and prevent degradation.

Appearance

Asterilized powder that is white or light brown, contained in a colorless, transparent vial.

Package unit

Vials - 10 vials/box [(1g/vial)*10]