Dapagliflozin and Metformin Extended-Release Tablets 10/1000 mg (Dapagliflozin Propanediol Monohydrate, Metformin Hydrochloride)

Adult dose

The dosage of this medication should be individualized based on the patient's current treatment, efficacy, and tolerability, without exceeding the maximum recommended dose of 10 mg of dapagliflozin and 2000 mg of extended-release metformin. It is generally administered once daily with the evening meal. The maximum dosage is 10 mg of dapagliflozin and 2000 mg of extended-release metformin once daily, taken as 2 tablets of 5 mg/1000 mg. For initial therapy

This medication helps in controlling blood sugar levels. Before taking this medication, it is essential to confirm that kidney function is normal. It should not be used in patients with severely impaired kidney function. It should not be used in cases of severe infection, dehydration, decreased heart function, acute myocardial infarction, and patients undergoing surgery should stop this medication 48 hours before the procedure. Pregnant or breastfeeding women should not take this medication. This medication can cause hypoglycemia and caution is particularly warranted when used with insulin or other blood glucose-lowering agents, and other medication dosages may need adjustment as necessary. While taking this medication, watch out for symptoms of dehydration or low blood pressure and regularly check fluid status and blood pressure. A rare but serious side effect called lactic acidosis can occur, so if symptoms like malaise, muscle pain, difficulty breathing, or abdominal pain occur, notify a doctor immediately. Genital and urinary tract infections may occur; thus, prompt treatment is necessary if infection symptoms are present. This medication may lower vitamin B12 levels, so it is recommended to regularly check vitamin B12 levels with long-term use. Alcohol may increase the risk of side effects from this medication, so it is advised to avoid excessive drinking while on this medication. During the use of this medication, consistent monitoring of blood sugar control is crucial, especially for elderly patients or those with decreased kidney function. In case of overdose, seek appropriate treatment at a medical institution immediately, and dialysis may be beneficial if necessary. This medication is not recommended for children as safety and efficacy have not been established.

Serious side effects

Severe lactic acidosis (with symptoms related to lactic acidosis such as malaise, muscle pain, difficulty breathing, asthenia, abdominal pain, hypothermia, hypotension, bradyarrhythmia), severe allergic reactions (such as hives, severe swelling, chest tightness, difficulty breathing, cold sweat, paleness), severe hypoglycemia, severe dermatological reactions (such as severe rash with fever, blisters, skin peeling, pain of oral/ocular mucosa), dyspnea or difficulty breathing, asthma attacks, cough and

Mild side effects

Genital infections such as vulvovaginitis, balanitis, urinary tract infection, hypoglycemia (particularly when combined with insulin or sulfonylureas), dizziness, constipation, dry mouth, low back pain, dysuria, polyuria, nocturia, pruritus, tendonitis, arthralgia, myalgia, headache, facial paralysis, peripheral neuropathy, sensory disturbances, drowsiness, tremors, upper abdominal pain, dyspepsia, abdominal discomfort, diarrhea, abdominal pain, salivary gland swelling, toothache, insomnia, palpitations, asthenia, fatigue, edema

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is advisable to maintain the storage temperature between 1°C and 30°C to keep the medication effective for a longer time.

Appearance

Yellow, oval, biconvex, extended-release film-coated tablet

Package unit

Box - 30 tablets/box [(10 tablets/PTP (Alu-Alu) x 3)]