Hyusigaduo Extended-Release Tablet 10/500 mg (Dapagliflozin, Metformin)

Adult dose

This medication is typically administered once daily with the evening meal. The maximum dosage is once daily dapagliflozin 10 mg / extended-release metformin 2000 mg, and 2 tablets of 5 mg/1000 mg. If there has been no prior antidiabetic medication treatment, the initial regimen is 5 mg/500 mg or 10 mg/500 mg once daily. To reduce gastrointestinal side effects of metformin, dosages should be adjusted gradually.

This medication is used in the treatment of diabetes, with the main ingredients being dapagliflozin and metformin. It should not be used in patients with impaired kidney function or certain serious diseases. This medication can very rarely cause a serious side effect known as lactic acidosis, so particular caution is needed in cases of impaired kidney or liver function. Lactic acidosis is a condition characterized by excessive accumulation of lactic acid in the body, with symptoms that may include fatigue, muscle pain, shortness of breath, and abdominal pain. Additionally, there is a risk of hypoglycemia when this medication is used with other antidiabetic drugs or insulin, so blood glucose levels should be monitored frequently, and dosages adjusted as needed. This medication can cause dehydration or low blood pressure; patients with a reduced volume of fluid or low blood pressure should consult a physician before administration. Special caution is needed for the elderly or patients taking diuretics. Genital or urinary infections may occur; if related symptoms arise, notify healthcare providers immediately. Furthermore, this medication may lower vitamin B12 levels, so regular checks of vitamin B12 levels are recommended during long-term use. Pregnant or breastfeeding women should not use this medication, and if pregnancy is planned or confirmed, they must inform their physician. Prior to surgery or contrast examinations, this medication should be discontinued for a specified period, and it should be restarted only after confirming normal kidney function. In cases of overdose, serious side effects can occur, so it is essential to adhere strictly to the prescribed regimen and dosages. Finally, alcohol intake should be avoided during the use of this medication, and caution should be exercised as dizziness and other symptoms may occur during driving or operating machinery.

Serious side effects

• Lactic acidosis
• severe hypoglycemia
• acute kidney injury
• renal impairment
• ketoacidosis
• urosepsis
• pyelonephritis
• severe edema
• severe allergic reactions
• severe skin adverse reactions

Mild side effects

• Vulvovaginitis
• balanitis
• related genital infections
• urinary tract infections
• fungal infections
• hypoglycemia
• thirst
• dizziness
• constipation
• dry mouth

This medication should be stored in a tightly sealed container to protect it from air and moisture. The recommended storage temperature is between 1 to 30 degrees Celsius at room temperature. This way, the drug's effectiveness and safety can be maintained for an extended period.

Appearance

Pink, double-convex, rectangular extended-release film-coated tablet

Package unit

Bottle - 30 tablets per bottle