Dapagliflozin Metformin Controlled-Release Tablet 10/1000 mg

Adult dose

The dosage of this medication should be individualized based on the patient’s treatment regimen, efficacy, and tolerability, without exceeding the maximum recommended dosage of dapagliflozin 10 mg and controlled-release metformin 2000 mg. Generally administered once daily with the evening meal. The maximum dosage is dapagliflozin 10 mg/control-release metformin 2000 mg once daily, with 2 tablets of 5 mg/1000 mg taken together. Previously treated with another diabetes medication.

This medication should not be administered to patients with impaired kidney function or serious infections, heart failure, etc. It may rarely cause a metabolic disorder known as lactic acidosis; therefore, kidney function should be routinely monitored, and healthcare professionals should be consulted immediately if any unusual symptoms occur. There is a risk of hypoglycemia when taken with insulin or sulfonylureas, so blood sugar levels should be closely monitored; dosage adjustments may be necessary. Patients with dehydration or low blood pressure should verify their hydration status and blood pressure before taking this medication and monitor for dizziness or hypotension symptoms during treatment. This medication may increase the risk of genitourinary infections; prompt treatment is necessary if any infection symptoms occur. Women who are pregnant or breastfeeding should not use this medication, and those planning for pregnancy or who may become pregnant should consult a healthcare professional. Elderly patients or those with impaired kidney function should have their dose carefully adjusted, and kidney function tests should be performed regularly. Avoid alcohol consumption while taking this medication, and if gastrointestinal discomfort or dehydration symptoms occur, temporarily discontinue use and consult with a healthcare professional. In case of overdose, seek appropriate medical treatment immediately, and this medication has not established safety for children, so it should not be used in that population. This medication may interact with other drugs, so it is essential to inform healthcare professionals of any other medications being taken.

Serious side effects

Hypoglycemia, decreased fluid volume (dehydration, hypovolemia, hypotension), diabetic ketoacidosis, ketosis, urosepsis, pyelonephritis, acute kidney injury, kidney dysfunction, rash, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor), severe skin adverse reactions (severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa), respiratory problems (shortness of breath or difficulty breathing)

Mild side effects

• Dizziness
• constipation
• dry mouth
• back pain
• pain during urination
• polyuria
• nocturia
• itching of the vulva
• itching of the genitals
• increased hematocrit

This medication is sensitive to air and humidity; therefore, it should be stored in a tightly closed container. It is recommended to maintain a storage temperature between 1 to 30 degrees Celsius. Proper storage can help maintain the efficacy of the medication for a longer period.

Appearance

Yellow, biconvex, oval controlled-release film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle