Dapagliflozin Metformin Extended-Release Tablet 10/1000 mg

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dose is once daily dapagliflozin 10 mg/extended-release metformin 2000 mg, taken as 2 tablets of 5 mg/1000 mg. If there is no prior experience with diabetes medications, the initial regimen should be one tablet of 5 mg/500 mg or 10 mg/500 mg once daily. To reduce gastrointestinal side effects associated with metformin, dose adjustments may be made.

This medication helps in the management of blood sugar levels. Caution is required as there is a rare possibility of severe lactic acidosis being a side effect when taking this medication. If taken with other diabetes medications, there may be a risk of hypoglycemia. This medication should not be used in specific patients. For instance, patients with severely impaired kidney function, those with dehydration or severe infections, type 1 diabetes patients, heart failure patients, women who are pregnant or nursing, and those with lactose intolerance should not take this medication. Additionally, caution is required for patients with mildly reduced kidney function or low fluid volume. Elderly patients or those on diuretics also need to be cautious. Symptoms of hypotension or changes in kidney function should be closely monitored during treatment with this medication. Genital infections or urinary tract infections may occur frequently while taking this medication. If symptoms of infection appear in the genitals or urinary tract, immediate treatment is necessary. Additionally, hypoglycemic symptoms may occur, thus maintaining proper blood sugar management is important. This medication can lead to dehydration or hypotension due to reduced fluid volume, so fluid status should be well managed, and in necessary cases, discontinuation of the medication may be required. Rarely, serious metabolic disturbances such as diabetic ketoacidosis may occur, so if symptoms like abdominal pain, vomiting, or breathing difficulties occur, consult a healthcare professional immediately. This medication may lower vitamin B12 levels, so it is advisable to check for vitamin B12 deficiency if used for a long period. Alcohol consumption may increase the risk of side effects associated with this medication and should be avoided. Pregnant or nursing women should not use this medication, and use should be discontinued upon confirmation of pregnancy. Elderly patients should be aware that declining kidney function is common; therefore, renal function should be regularly monitored before and after use, and dosage adjustments may be necessary. In case of overdose, appropriate treatment should be administered, particularly since the metformin component can be removed through dialysis. This medication does not significantly affect driving or machinery operation, but caution is advised due to the possibility of dizziness. Finally, this medication should be kept out of the reach of children and maintained in its original container to preserve quality.

Serious side effects

• Lactic acidosis
• severe hypoglycemia
• ketoacidosis
• acute kidney injury
• impaired kidney function
• urosepsis
• pyelonephritis
• rash
• severe skin reactions
• Guillain-Barré syndrome

Mild side effects

Vulvitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, thirst, dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, pruritus of the vulva, pruritus of the genitalia, elevated hematocrit, reduced initial renal creatinine clearance, dyslipidemia, elevated blood creatinine, elevated blood urea, weight loss, diarrhea, nausea/vomiting, decreased vitamin B12/deficiency

Store this medication in a tightly closed container to avoid contact with air or moisture. It is recommended to maintain a storage temperature between 1 to 30 degrees Celsius at room temperature.

Appearance

Yellow, oval-shaped, double-convex extended-release film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle