Dapagliflozin 10mg (Dapagliflozin Propanediol Hydrate)

Adult dose

The recommended dosage of this medication is 10mg once daily for monotherapy and additional combination therapy. In initial combination therapy with metformin, the dosage is 5mg or 10mg once daily. There are dosage adjustment guidelines based on renal impairment, liver impairment, and elderly status, but the basic dosage remains the same. This medication can be taken orally once daily at any time, regardless of food intake, and should be swallowed whole.

Child dose

The efficacy and safety in children under 18 years have not been established. Therefore, there is no recommended dosage.

This medication should not be used in patients who are allergic to its active ingredients or excipients. Do not administer this medication to patients with type 1 diabetes or diabetic ketoacidosis. This medication contains lactose and should not be used in patients with genetic problems such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. This medication should not be administered to patients undergoing dialysis. Caution is required when using this medication in patients with reduced fluid volume or impaired renal function. This medication can cause a decrease in blood pressure or intravascular blood volume, and caution is especially needed in elderly patients with impaired renal function or those taking diuretics. Fluid volume and renal function should be evaluated before administration, and symptoms of hypotension and renal function should be continuously monitored after administration. In patients with moderate to severe renal impairment, the blood sugar control effect of this medication may be reduced, so caution is necessary. When using this medication, symptoms like genital infections, urinary tract infections, hypoglycemia, decreased fluid volume, and diabetic ketoacidosis may occur, so symptoms should be monitored carefully. Genital infections may be more common in women and patients with a history of such conditions. The risk of hypoglycemia may increase when used in conjunction with blood glucose-lowering agents like insulin or sulfonylureas, necessitating dosage adjustments. This medication may induce dehydration or hypotension due to decreased fluid volume; therefore, patients with unstable fluid status should consider discontinuation of treatment. Diabetic ketoacidosis may occur even if blood sugar levels are not high, so immediate examination and treatment are required when related symptoms are present. Severe urinary infections such as urinary tract infections and pyelonephritis have also been reported, so prompt treatment is needed if infection symptoms appear. In case of severe infection symptoms like necrotizing fasciitis, administration of the medication should be immediately stopped and appropriate treatment should be sought. Elderly patients should be managed more carefully due to the higher risk of renal function decline and decreased fluid volume. Pregnant women should not use this medication, and if pregnancy is confirmed, treatment should be discontinued immediately. Breastfeeding women are also advised against using this medication. Safety and efficacy in children and adolescents have not been adequately established, so there is no dosage for these age groups. In case of overdose, there is no specific antidote; appropriate treatment should be administered according to symptoms, and there is no research on whether this medication can be removed by dialysis. This medication does not significantly affect the ability to drive or operate machinery, but caution is required when taken with insulin or sulfonylureas due to the risk of hypoglycemia. This medication should be stored in its original container and kept out of the reach of children.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, oral/ocular mucosal pain, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of the skin or eyes), extreme fatigue, sudden and severe headaches, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, reduced urine output

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, dizziness, constipation, dry mouth, flank pain, dysuria, polyuria, nocturia, increased hematocrit, decreased early treatment renal creatinine clearance, dyslipidemia, increased serum creatinine, increased blood urea, weight loss, chest pain, cough, palpitations, insomnia, fatty liver, gallbladder polyps, tinnitus, indigestion, nausea, diarrhea, vomiting,

This medication should be stored in a tightly sealed container to protect it from air and moisture, ideally at room temperature between 1 to 30 degrees Celsius. By storing it this way, the effectiveness of the medication can be safely maintained.

Appearance

Yellow, double-convex, diamond-shaped film-coated tablet

Package unit

30 tablets/PPT [10 tablets/PPT × 3]