Dapagliflozin/Metformin Extended-release Tablet 10/1000 mg

Adult dose

Administer once daily with the evening meal. The maximum dosage is Dapagliflozin 10 mg, extended-release Metformin 2000 mg. The initial recommended dosage is 1 tablet of 5 mg/500 mg or 10 mg/500 mg once daily. For patients already treated with Metformin, Dapagliflozin 10 mg is administered once daily. Tablets should be swallowed whole and not crushed, cut, or chewed. Dosage adjustments may be necessary based on kidney function.

This medication helps control blood sugar levels. However, it should not be used in patients with impaired kidney function, dehydration, severe infections, or acute heart diseases. Pregnant or breastfeeding women should also not take this medication. Regular kidney function tests are necessary while taking this medication, and any decrease in body fluid or symptoms of hypotension should be discussed with a physician. There is a risk of hypoglycemia when taken with insulin or sulfonylurea, so dosage adjustments may be necessary. This medication may lead to genital infections or urinary tract infections, and immediate treatment should be sought for any signs of infection. During treatment, vitamin B12 levels may decrease, so regular monitoring is advisable. Excessive alcohol consumption may increase the risk of side effects, so it should be avoided. When undergoing surgery or radiologic contrast examinations, it is necessary to suspend the use of this medication for a period of time and perform kidney function tests before resuming use. Dizziness or symptoms of hypotension may occur, so caution is needed while driving or operating machinery. This medication should be kept out of reach of children and stored in its original container for safety.

Serious side effects

• Severe lactic acidosis
• severe hypoglycemia
• lactic acidosis
• acute kidney injury
• renal impairment
• diabetic ketoacidosis
• ketosis
• urosepsis
• pyelonephritis
• perineal necrosis

Mild side effects

• Vulvitis
• balanitis and related genital infections
• urinary tract infections
• hypoglycemia
• dizziness
• constipation
• dry mouth
• lower back pain
• dysuria
• polyuria

This medication should be stored in a sealed container to protect it from air and moisture. It is essential to maintain a storage temperature between 1 and 30 degrees Celsius to preserve the medication's effectiveness and prevent deterioration.

Appearance

Yellow, oval-shaped, bilaterally convex extended-release film-coated tablet

Package unit

30 tablets/box [(6 tablets/PTP*5)], 30 tablets/bottle, 200 tablets/bottle