Dapaenmet Extended-Release Tablet 10/1000 mg (Dapagliflozin, Metformin)

Adult dose

This medication is generally taken once daily with the evening meal. The maximum dosage is once daily dapagliflozin 10 mg/extended-release metformin 2000 mg, taken as two tablets of 5 mg/1000 mg. When used as initial therapy, the recommended starting dosage is one tablet of 5 mg/500 mg or 10 mg/500 mg once daily. To reduce gastrointestinal side effects of metformin, dose adjustments should be made gradually.

This medication helps manage blood sugar levels. Before taking it, kidney function must be checked. If renal function is poor, the drug may accumulate in the body, posing risks. It should not be used during acute illnesses such as severe infection, dehydration, heart problems, or acute myocardial infarction. It is not to be administered to pregnant or nursing women. This medication contains lactose, so patients with lactose intolerance should avoid taking it. When taken with insulin or sulfonylureas, the risk of hypoglycemia may increase, necessitating caution. During treatment, genital and urinary tract infections may develop, so immediate treatment is required if symptoms arise. Signs of reduced fluid volume or hypotension may occur, particularly if dehydrated. A rare side effect called lactic acidosis may occur; if symptoms like fatigue, muscle pain, shortness of breath, or abdominal pain arise, consult a physician immediately. Vitamin B12 levels may decrease; thus, regular blood tests are advised during long-term use. Alcohol can increase the risk of side effects, so excessive drinking should be avoided during treatment. Before undergoing surgery or imaging tests with contrast agents, the medication should be discontinued for a period, and it may be restarted once normal kidney function is confirmed. Older adults or those with diminished renal function require dose adjustments and monitoring of kidney function. In case of overdose, seek medical treatment immediately. The safety of this medication has not been established for children, so it should not be used in pediatric populations. Dizziness may occur during treatment, necessitating caution when driving or operating machinery. Keep this medication out of the reach of children and store it in its original container to prevent misuse and degradation of quality.

Serious side effects

• Severe lactic acidosis
• Severe hypoglycemia
• Diabetic ketoacidosis
• Urosepsis and pyelonephritis
• Acute kidney injury and renal impairment
• Severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor)
• Severe skin reactions (severe rash accompanied by fever, blistering, skin peeling, mouth/eye mucosa pain)
• Respiratory issues (shortness of breath or difficulty breathing, asthma attacks, breathing difficulties associated with coughing and fever)

Mild side effects

• Vulvovaginitis, balanitis and related genital infections
• Urinary tract infection
• Fungal infections
• Hypoglycemia
• Decreased fluid volume (dehydration, hypovolemia, hypotension)
• Dizziness
• Constipation
• Dry mouth
• Lower back pain
• Dysuria

This medication may be sensitive to air and moisture; therefore, it must be stored in a tightly sealed container. It is important to maintain storage temperatures between 1 to 30 degrees Celsius to preserve the medication's effectiveness and safety.

Appearance

Yellow, oval-shaped, bilayer, extended-release film-coated tablets

Package unit

30 tablets/box [(6 tablets/PTP*5)], 30 tablets/bottle, 200 tablets/bottle