Diphyton 10 mg (Dapagliflozin Propanediol Hydrate)

Adult dose

The recommended dosage of this medication for monotherapy and as an add-on therapy with other antidiabetic agents such as insulin is 10 mg once daily. If there is no prior experience with antidiabetic medication, when used in combination with metformin, the initial dosage is either 5 mg once daily or 10 mg once daily. For patients with chronic heart failure and chronic kidney disease, the dosage is 10 mg once daily. Dosage adjustments may be made for renal impairment, liver impairment, and the elderly.

Child dose

The efficacy and safety of dapagliflozin in children under 18 years of age have not been established. There is no relevant data.

This medication should not be administered to certain patients. People with allergies to the active ingredients or excipients of this medication, type 1 diabetes patients, patients with diabetic ketoacidosis, individuals with genetic lactose intolerance, and patients undergoing dialysis should not use this medication. Caution should be exercised in patients with decreased fluid volume or impaired kidney function. In particular, patients with significantly impaired kidney function, the elderly, and those taking diuretics may be at increased risk for hypotension or kidney damage, so their condition should be closely monitored before and during administration. This medication may increase the risk of genital and urinary tract infections, so if symptoms of such infections appear, medical personnel should be informed immediately. When used with insulin or sulfonylureas that have a risk of hypoglycemia, hypoglycemic symptoms should be closely monitored, and if necessary, the dose of such medications should be adjusted. Due to the potential for dehydration or hypotension from decreased fluid volume, particularly elderly patients or those taking antihypertensive medications should regularly check their blood pressure and fluid status. This medication can cause a serious metabolic disorder known as diabetic ketoacidosis, so if symptoms such as vomiting, abdominal pain, or difficulty breathing occur, immediate medical care should be sought. Pregnant or breastfeeding women are advised not to use this medication, and if pregnancy is confirmed, administration should be immediately discontinued. In children, the safety and efficacy of dapagliflozin have not been sufficiently established, so it is not used. In case of overdose, there are no specific antidotes, but appropriate treatment is needed based on symptoms, and rapid treatment should be administered for dehydration or hypotension. Finally, this medication should be stored out of the reach of children and maintained in its original container to preserve quality.

Serious side effects

Rash, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with fever, blisters, peeling skin, pain in mouth/eyes mucosa, shortness of breath or difficulty breathing, asthma attacks, cough accompanied by fever, respiratory abnormalities, jaundice (yellowing of the skin or eyes), severe lethargy, sudden and severe headache, lightning headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

• Vulvovaginitis
• balanitis and related genital infections
• urinary tract infections
• fungal infections
• hypoglycemia
• thirst
• dizziness
• constipation
• dry mouth
• back pain

This medication may be sensitive to air and moisture, so it should be stored in a sealed container. Additionally, to maintain the drug's effectiveness, it is important to store it at a cool room temperature, specifically between 1 to 30 degrees Celsius.

Appearance

Yellow, biconvex, diamond-shaped film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle, 28 tablets/box[((7 tablets/Alu-Alu)×4)]