Sitagliptin Plus Tablet 50/850 mg (Sitagliptin, Metformin)

Adult dose

This medication is generally taken twice daily with food, and the dosage is gradually increased to reduce gastrointestinal adverse reactions caused by metformin. 1. Patients not currently treated with metformin: - Initial dosage is to take this medication 50/500 mg twice a day, with one tablet each time, and it can be increased to 50/1000 mg twice a day, with one tablet each time. 2. Patients being treated with metformin

This medication contains two ingredients, sitagliptin and metformin. First, sitagliptin can cause a rare but severe allergic reaction, so if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur within 3 months of administration, the medication should be discontinued immediately and a doctor should be consulted. Moreover, sitagliptin can cause a serious side effect known as acute pancreatitis, which is inflammation of the pancreas. If symptoms such as abdominal pain, nausea, vomiting, or loss of appetite occur, notify healthcare personnel promptly. Metformin can cause a rare but fatal metabolic disorder called lactic acidosis, and this medication should not be taken if there is impaired kidney function, liver disease, dehydration, or severe infection. Also, if there is sudden dehydration, severe diarrhea, or vomiting, the medication should be stopped and a doctor consulted. This medication should not be administered to patients with moderate to severe renal impairment, and regular kidney function tests should be conducted. Special caution is necessary for elderly patients or those with weakened kidney function. Alcohol consumption should be avoided while taking this medication, and the medication should be temporarily stopped around the time of sudden surgery or radiologic investigations involving contrast agents. Additionally, because there is a risk of hypoglycemia, meals should be eaten regularly, and when taken together with other hypoglycemic agents or insulin, care should be taken for signs of hypoglycemia. Symptoms of hypoglycemia may include dizziness, cold sweat, tremor, and fatigue, and if they occur, take sugar immediately and consult healthcare personnel. This medication is not to be administered to pregnant women or women who may become pregnant, as well as to nursing mothers. Finally, any unusual skin rashes, severe joint pain, or blisters around the mouth while taking this medication should be reported to a doctor immediately. During the course of this medication, it is important to regularly check blood sugar levels, kidney function, liver function, and vitamin B12 levels and consult healthcare personnel quickly if any discomfort occurs.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, acute and fatal pancreatitis, acute renal failure, difficulty breathing, severe skin adverse reactions (Stevens-Johnson syndrome, rashes, cutaneous vasculitis, blistering similar to pemphigus), severe hypoglycemia, jaundice, elevated liver enzymes, severe headaches, altered consciousness, seizures, vision changes, paralysis, severe edema, elevated blood pressure

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• headache
• upper respiratory infection
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in a tightly closed container to keep out air and moisture, and the storage temperature should be maintained between 1 degrees Celsius and 30 degrees Celsius. By storing it this way, the effectiveness of the medication can be maintained for a longer period.

Appearance

Oval film-coated tablet in dark pink color

Package unit

56 tablets/box [(14 tablets/PTP x 4)], 30 tablets/bottle, 200 tablets/bottle