Janumet Tablets 50/1000 mg

Adult dose

This medication is generally taken twice daily with food and the dosage is gradually increased to reduce gastrointestinal adverse reactions caused by metformin. The initial dosage is determined based on the patient's current treatment regimen. 1. For patients not treated with metformin: Start with 1 tablet (50/500 mg) twice daily, with the potential to increase to 50/1000 mg. 2. For patients already on metformin treatment: Sitagliptin

This medication contains both sitagliptin and metformin hydrochloride to help regulate blood glucose levels. First, when taking this medication, severe allergic reactions may occur. If symptoms such as rash, difficulty breathing, or swelling of the face or lips develop, you must stop taking the medication immediately and consult a doctor. Moreover, serious side effects such as pancreatitis have been reported, so if symptoms like upper abdominal pain, vomiting, or nausea occur, you must visit a hospital immediately. Due to the metformin component, a rare but potentially fatal metabolic complication known as lactic acidosis can occur. Symptoms such as sudden fatigue, muscle pain, difficulty breathing, and abdominal pain should prompt immediate discontinuation of the medication and notification to the healthcare provider. Patients with poor kidney function or those suffering from acute illness, dehydration, or severe infections should not take this medication, and patients with impaired kidney function should undergo regular kidney function tests. This medication is not to be given to pregnant women or women who may become pregnant, nor to breastfeeding women. Additionally, this medication should be discontinued for a certain period before and after surgery, and only resumed after normal kidney function is confirmed post-surgery. While taking this medication, hypoglycemia may occur due to irregular meals, intense exercise, or interactions with other medications, so careful monitoring of blood glucose levels is necessary. Particularly when taken with insulin or sulfonylurea derivatives, the risk of hypoglycemia increases, and dose adjustments should be discussed with a doctor. During the course of treatment, side effects such as diarrhea, nausea, vomiting, headache, and upper respiratory infections may occur; if symptoms are severe or persistent, consult a healthcare provider. Lastly, avoiding excessive alcohol consumption while taking this medication is crucial, and regular blood tests and kidney function checks are essential to detect any signs early.

Serious side effects

Urticaria, severe hypersensitivity reactions (including anaphylaxis, angioedema, Stevens-Johnson syndrome, including exfoliative skin diseases), acute pancreatitis (including fatal/non-fatal hemorrhagic or necrotizing pancreatitis), acute renal failure, dyspnea, severe joint pain with disability, bullous pemphigoid, thrombocytopenia, rhabdomyolysis, lactic acidosis, severe edema, acute worsening of renal function, hepatic abnormalities (increase in liver enzymes, potential for jaundice), severe

Mild side effects

• Nausea
• vomiting
• diarrhea
• headache
• upper respiratory infection
• nasopharyngitis
• abdominal pain
• decreased appetite
• itching
• dizziness

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is best to keep it at room temperature between 1 and 30 degrees Celsius, as this helps preserve the medication's effectiveness.

Appearance

Dark red, oval film-coated tablets

Package unit

56 tablets/box [(14 tablets/PTP x 4)], 30 tablets/bottle, 200 tablets/bottle