Poshuvet Duo Sustained Release Tablet 5/500 mg

Adult dose

This drug is typically administered once daily with the evening meal. The maximum dose is once daily dapagliflozin 10 mg/sustained-release metformin 2000 mg, administered as 2 tablets of 5 mg/1000 mg. If the patient has not previously received diabetes medication, the initial therapy is one tablet of 5 mg/500 mg or 10 mg/500 mg, taken once daily. To reduce gastrointestinal side effects of metformin, dosage should be gradually increased.

This drug is used to treat diabetes and helps to control blood sugar. However, it may very rarely cause a dangerous condition known as lactic acidosis, so caution is necessary. Additionally, when used in conjunction with insulin or other diabetes medications, hypoglycemia may occur. This drug should not be used in patients with severely impaired kidney function, or those with acute illnesses such as dehydration or serious infections. Pregnant or breastfeeding women should also avoid this medication. Before taking this drug, it is crucial to check fluid status and kidney function, and symptoms of hypotension or changes in kidney function should be monitored closely during treatment. In particular, dosage should be adjusted carefully for elderly patients or those with impaired kidney function. This drug may increase the risk of genital infections and urinary tract infections; hence, any signs of infection should prompt immediate consultation with a physician. Furthermore, this drug may lower vitamin B12 levels, so regular monitoring of vitamin B12 is advisable during prolonged use. Excessive alcohol consumption increases risks, so alcohol should be avoided during treatment. Before and after surgical or radiological contrast examinations, discontinuation of this drug for a period is needed, followed by checking kidney function before resuming it. While taking this drug, patients should monitor for symptoms of hypoglycemia and dehydration, and report any abnormal signs to healthcare providers immediately. Lastly, safety has not been established in children and pregnant women, and careful management is necessary for the elderly.

Serious side effects

• Guillain-Barré syndrome
• neurological disorders
• diabetic ketoacidosis
• acute cholecystitis
• urosepsis
• pyelonephritis
• acute kidney injury
• impaired kidney function
• chest pain
• tightness in the chest

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, decreased fluid volume, thirst, dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, vulvar itching, genital itching, elevated hematocrit, increased blood creatinine at treatment initiation, dyslipidemia, elevated blood urea, weight loss, rash, diarrhea, nausea/vomiting, decreased/deficient vitamin B12, upper abdominal pain, digestive discomfort

This drug may be sensitive to air or moisture, so it should be stored in a sealed container. The recommended storage temperature is at room temperature between 1 degree and 30 degrees. Proper storage helps maintain the drug's effectiveness for a longer period.

Appearance

Orange, biconvex, egg-shaped film-coated tablet

Package unit

30 tablets/bottle