Ploglimet Extended Release Tablet 5/500 mg

Adult dose

The dosage of this medication should be individualized based on the patient's current therapy, efficacy, and tolerability, without exceeding the maximum recommended dosage of 10 mg dapagliflozin and 2000 mg extended-release metformin. Generally, it is administered once daily with the evening meal. The maximum dosage is 10 mg dapagliflozin/2000 mg extended-release metformin once daily, administered as 2 tablets of 5 mg/1000 mg. Initial diabetes treatment.

This medication is used for the treatment of diabetes and should not be used in patients with poor kidney function or acute illness. While taking this medication, severe hypoglycemia or lactic acidosis can occur rarely, so if symptoms appear, immediate consultation with a doctor is necessary. It is especially safe not to administer this medication to patients with impaired kidney function, those in a dehydrated state, patients with cardiovascular issues, patients with liver dysfunction, and women who are pregnant or breastfeeding. The risk of hypoglycemia may increase when this medication is taken in conjunction with insulin or sulfonylureas, so dosage adjustments may be required. During treatment, symptoms of decreased fluid volume or hypotension may occur, making it important to regularly monitor blood pressure and kidney function. Additionally, genital infections or urinary tract infections may arise, so prompt treatment is needed when infection symptoms occur. This medication may decrease vitamin B12 levels, so monitoring vitamin B12 concentrations during long-term use is advisable. Excessive alcohol intake may increase the risk of side effects from this medication, so alcohol should be avoided during use. If undergoing surgery or contrast examinations, this medication should be temporarily discontinued for a certain period, and resumption should occur only after confirming normal kidney function. Elderly patients or those with decreased kidney function must have dosage adjustments and close monitoring of kidney function. While taking this medication, dizziness or hypoglycemia symptoms may occur, so caution is advised when driving or operating machinery. Keep out of reach of children and store in the original container to maintain the drug's quality and safety.

Serious side effects

Severe lactic acidosis (lactic acidosis), severe hypoglycemia, acute kidney injury, renal dysfunction, diabetic ketoacidosis, perineal necrosis, urosepsis and pyelonephritis, acute cholecystitis, atrial fibrillation, Guillain-Barré syndrome, severe allergic reactions (hypersensitivity), liver abnormalities (jaundice), serious neurological symptoms (headache, seizures, confusional state, visual disturbances, paralysis), severe edema or urinary abnormalities

Mild side effects

Vulvovaginitis, balanitis and associated genital infections, urinary tract infections, fungal infections, hypoglycemia, dry mouth, dizziness, constipation, back pain, dysuria, polyuria, nocturia, vulvar itching, genital itching, increased hematocrit, dyslipidemia, elevated serum creatinine, elevated blood urea, weight loss, diarrhea, nausea/vomiting, decreased/deficiency of vitamin B12, upper abdominal pain, dyspepsia, abdominal discomfort, abdominal pain, hypersensitivity

This medication should be stored in a tightly sealed container to prevent air or moisture entry, ideally at room temperature between 1 degree Celsius and 30 degrees Celsius. Storing it this way helps to maintain the medication's effectiveness over time.

Appearance

Orange, biconvex, egg-shaped film-coated tablet

Package unit

30 tablets/bottle