Esomezol-Dial Extended Release Capsule 10 mg (Esomeprazole Magnesium Trihydrate)

Adult dose

1 capsule once, once a day taken orally. This medication can be taken regardless of meals. It should be swallowed with liquids such as water and should not be chewed or crushed. Patients who have difficulty swallowing capsules may open the capsule and take the contents mixed in half a cup of non-carbonated water. Other beverages should not be used as they may dissolve the enteric coating. After opening the capsule and placing the contents in water, it should be stirred and immediately swallowed without chewing, and the cup should be rinsed with half a cup of non-carbonated water and consumed again. The drug particles floating in water should not be chewed or crushed during consumption. 1. Adults: Take 1 capsule orally once a day. 2. Children under 12 years: There is no experience of administering this medication to children under 12 years of age. 3. Renal impairment: There is no need to adjust the dosage. Since there are not many cases of administration to patients with severe renal failure, it should be administered with caution. 4. Hepatic impairment: There is no need to adjust the dosage for patients with mild to moderate hepatic impairment. Administration should be done carefully for patients with severe hepatic impairment. 5. Elderly: There is no need to adjust the dosage.

Child dose

There is no experience of administering this medication to children under 12 years of age.

This medication should not be administered to certain patients. Patients who are hypersensitive to this drug or its components, or who have a history of hypersensitivity to benzimidazole derivatives should not take it. Patients currently taking medications containing atazanavir, nelfinavir, or rilpivirine should not use this medication in combination. Women who are breastfeeding should not take this medication. When administering this medication, various adverse reactions may occur, hence caution is needed. Gastrointestinal disturbances may cause abdominal discomfort, bloating, and diarrhea. Neurological and systemic symptoms such as headache, dizziness, and pharyngitis may also occur. Rarely, serious side effects such as blood disorders, hypersensitivity reactions, hypomagnesemia, mental confusion, skin rashes, fractures, and liver dysfunction have been reported. Regular check-ups are required during long-term use, especially if taken for more than one year, as the risk of hypomagnesemia or fractures may increase. This medication suppresses gastric acid secretion, lowering the acidity in the stomach, which may slightly increase the risk of gastrointestinal bacterial infections. Additionally, symptoms of malignancy may be masked or diagnosis may be delayed, so careful evaluation is required in patients with suspicious symptoms among those with gastric ulcers. This medication may interact with various drugs, so if taking other medications, it is essential to consult a physician or pharmacist. Particularly, caution is needed when used in combination with warfarin, digoxin, methotrexate, clopidogrel, as there may be changes in blood concentration or risk of side effects. Data on the safety of this medication during pregnancy are limited, so it should be administered cautiously to pregnant women, and breastfeeding women should avoid taking it. In the event of overdose, there is no specific antidote, so treatment should be symptomatic and general supportive care should be implemented. This medication should be stored out of reach of children, and transferring it to another container is not advisable as it may affect quality.

Serious side effects

Urticaria, angioedema, anaphylaxis, shock, urticaria, mucocutaneous syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Lyell's syndrome, acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS), jaundice, hepatitis, hepatic failure, subarachnoid hemorrhage, severe headache, seizures, altered consciousness, visual disturbances, paralysis, facial edema, severe edema, Clostridioides difficile-associated diarrhea

Mild side effects

• Abdominal discomfort
• abdominal bloating
• diarrhea
• chest pain
• pharyngitis
• dizziness
• headache
• oropharyngeal pain
• leukopenia
• thrombocytopenia

This medication must be stored in a tightly closed container to protect it from air and moisture. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

An extended-release hard capsule with a white or pale yellow tablet and a cloudy pink tablet, with a white upper and lower body.

Package unit

30 capsules per bottle