Olimel N12

Adult dosage

The recommended daily dosage varies depending on the patient's nutritional status and catabolic state: nitrogen of 0.16 g-0.35 g per kg of body weight (Amino acids 1 g-2 g per kg), total calories of 20-40 kcal per kg of body weight, and total volume of 20-40 mL per kg of body weight or 1-1.5 mL per consumed kcal. The maximum daily dosage is 26 mL per kg of body weight (Amino Acids 2.0 g, Glucose 1.9

Children's dosage

For children over 2 years, the dosage for nitrogen and calorie requirements decreases as age increases. The maximum daily dosage for children aged 2 to 11 years is 33 mL per kg of body weight (Amino Acids 2.5

This medication must be used according to a physician's instructions. If signs of anaphylactic reactions such as fever, chills, rash, or difficulty breathing appear during administration, administration should be stopped immediately. This medication may cause precipitation when administered with intravenous calcium-containing agents like ceftriaxone; therefore, it must not be administered simultaneously using the same infusion device. If the same infusion line must be used for continuous infusion, the infusion line must be thoroughly cleaned before and after administration. Preterm infants and low-birth-weight infants may experience increased levels of free fatty acids in the blood due to slow metabolism of the lipid components of this medication, which could lead to lipid accumulation in the pulmonary vessels in severe cases and pose a risk. This drug should not be administered to premature infants, neonates, or children under 2 years of age, nor to patients allergic to eggs, soybeans, peanuts, corn, or components of this medication. Administration is contraindicated in patients with certain diseases such as severe renal impairment, liver disease, congenital amino acid metabolism disorders, blood coagulation disorders, hypertriglyceridemia, and hyperglycemia. This medication should be administered cautiously in patients with metabolic disorders such as renal failure, diabetes, pancreatitis, decreased liver function, hypothyroidism, sepsis, heart failure, and lung failure, and electrolyte and fluid status must be stable prior to administration. Overdosage or rapid infusion may cause side effects; care should be taken, and if symptoms such as sweating, fever, chills, headache, rash, or difficulty breathing appear during initial administration, infusion should be stopped immediately. Fluid and electrolyte balance, blood glucose, liver and kidney function, and blood coagulation status must be regularly monitored throughout the administration period. This medication should be infused through a central vein, not a peripheral vein, and if extravasation occurs, infusion should be stopped immediately, and appropriate treatment should be provided. Safety during pregnancy and lactation has not been established; therefore, it should only be given if the benefits of therapy exceed the risks. In pediatric cases, administration should not be done for those under 2 years of age, while for those 2 years and older, pediatric formulations should be used, and vitamins and trace elements must be supplemented. This medication contains corn-derived glucose and may trigger allergic reactions in patients with corn allergies, so caution is required. Symptoms such as acidosis, excessive circulating blood volume, and hyperglycemia may occur in case of overdose, and blood dialysis may be required if necessary. This medication contains vitamin K but does not significantly affect the effect of anticoagulants in the coumarin class. Aseptic procedures must be strictly followed during administration to prevent infections and sepsis, with special attention required for catheter management. Care must be taken to avoid interactions when co-administered with other medications, especially regarding precipitation, and it should not be administered with ceftriaxone, ampicillin, or fosphenytoin.

Serious side effects

Anaphylactic reactions (fever, chills, rash, difficulty breathing), severe allergic reactions, vesicles/bullae, severe skin adverse reactions, difficulty breathing, hypersensitivity reactions including respiratory distress, jaundice, liver abnormalities, sudden and severe headache, seizures, confusion of consciousness, visual disturbances, paralysis, serious neurological symptoms, significantly decreased urine output, severe generalized swelling (edema), elevated blood pressure, severe edema or urination abnormalities, sepsis

Mild side effects

Hyperhidrosis, fever, chills, headache, skin rash (erythematous, papular, pustular, macular, generalized rash), itching, flushing, tachycardia, loss of appetite, hypertriglyceridemia, abdominal pain, diarrhea, nausea, vomiting, hypertension, pain, irritation, swelling/edema, erythema/warmth, skin necrosis, inflammation, induration, skin tugging

This medication should be stored in a sealed container and kept at room temperature. Also, care must be taken to prevent freezing.

Appearance

A transparent plastic bag containing a solution, separated into three compartments by two membranes, where the amino acid solution and sugar solution are transparent, colorless to pale yellow liquids, and the fat solution is a homogeneous milky white.

Package unit

650 mL/bag [Amino Acid Solution 347 mL, Sugar Solution 173 mL, Fat Solution 130 mL], 1000 mL/bag [Amino Acid Solution 533 mL, Sugar Solution 267 mL, Fat Solution 200 mL], 1500 mL/bag [Amino Acid Solution 800 mL, Sugar Solution 400 mL, Fat Solution 300 mL], 2000 mL/bag [Amino Acid Solution 1,067 mL, Sugar Solution 533 mL, Fat Solution 400 mL]