Kasept 5 mg, 10 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mL (5 mg) once daily before bedtime. For 4 to 6 weeks, administer 5 mL (5 mg) dose. After the clinical response during this period has been evaluated, the dose can be increased to 10 mL (10 mg). When increasing to a daily dose of 10 mL (10 mg), caution should be taken regarding gastrointestinal adverse reactions. Underweight female patients over 85 years old should not exceed 5 mL (5 mg) per day.

Child dose

There is no experience of use in children.

This medication is used to treat symptoms of Alzheimer's type dementia with Donepezil Hydrochloride as the main ingredient. It should not be used in patients with allergies to Donepezil hydrochloride or piperidine derivatives, or any component of this medication. Pregnant women or women who may become pregnant and those who are breastfeeding should not take this medication and must consult a doctor if necessary. Patients with heart disease or heart conduction disorders should use this medication with caution, as it may cause bradycardia or arrhythmia. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should also be cautious because this medication may stimulate gastric acid secretion, worsening their symptoms. Patients with asthma or obstructive pulmonary disease may experience worsened respiratory symptoms due to the effects of this drug, so it should be administered carefully. Patients with extrapyramidal disorders such as Parkinson's disease should use this medication under a doctor's guidance as it may exacerbate their symptoms. This medication can significantly affect the heart, potentially leading to serious side effects like fainting, bradycardia, heart block, or heart failure, so any abnormal symptoms must be reported to a doctor immediately. Gastrointestinal side effects can include peptic ulcers, gastrointestinal bleeding, nausea, vomiting, and diarrhea, requiring caution. Liver function impairment or jaundice may occur, so liver health should be checked periodically. Neurological side effects may include seizures, movement disorders, hallucinations, insomnia, anxiety, depression, among other psychiatric symptoms. This medication can affect driving or operating machinery skills, so caution is advised at the beginning of treatment or when adjusting the dose. There may be potential interactions with other medications, especially those affecting CYP3A4 or CYP2D6 enzymes, requiring expert guidance when taken together. In cases of overdose, dangerous symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur, necessitating immediate treatment. This medication is not used in children as safety has not been established.

Serious side effects

• Hives
• severe swelling (edema)
• tightness in the chest
• difficulty breathing
• bradycardia
• heart block
• prolonged QT interval
• myocardial infarction
• heart failure
• peptic ulcer

Mild side effects

• Loss of appetite
• hallucinations
• agitation
• aggressive behavior
• anxiety
• insomnia
• drowsiness
• increased libido
• talkativeness
• mania

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, and the storage temperature should be maintained between 1 to 30 degrees Celsius. Storing it this way helps maintain the drug's effectiveness and prevents deterioration.

Appearance

A colorless or pale yellow liquid contained in an aluminum foil pouch.

Package unit

30 packets/box [5 mL/packet x 30], 30 packets/box [10 mL/packet x 30]