Tenireum Sustained-release Tablets 10/750 mg

Adult dose

This medication is generally administered once daily with the evening meal and is gradually adjusted to reduce gastrointestinal side effects associated with metformin. The 20/1000 mg sustained-release tablet is taken once daily as 1 tablet. Patients taking the 10/750 mg or 10/500 mg sustained-release tablets should take 2 tablets simultaneously once daily. For patients who cannot achieve sufficient blood sugar control with metformin monotherapy, the initial dose of this medication should provide 20 mg of teneligliptin once daily and the existing dosage of metformin. For patients switching from combination therapy of teneligliptin and metformin to this medication, the dosage may start at the existing dose of teneligliptin and metformin. Conversion from immediate-release metformin to this sustained-release formulation requires careful monitoring of blood sugar control and appropriate dosage adjustments. If administered with sulfonylureas, dosage reduction of sulfonylureas may be considered to minimize the risk of hypoglycemia. The maximum recommended daily dosage is 20 mg of teneligliptin and 2000 mg of sustained-release metformin. The safety and efficacy of this medication have not been specifically evaluated in patients who have switched from other blood sugar-lowering medications. Any changes during treatment of type 2 diabetes should be monitored closely, as they may induce changes in blood sugar control. To maintain sustained-release characteristics, this medication should be swallowed whole and not divided, crushed, chewed, or broken.

This medication helps control blood sugar levels and is used for diabetic patients. However, it may rarely cause a serious condition known as lactic acidosis, so caution is necessary. Lactic acidosis is a dangerous condition that occurs when there is excessive buildup of lactic acid in the body; if symptoms occur, medical attention should be sought immediately. Additionally, when used with other diabetes medications, hypoglycemia may occur, so blood sugar levels should be monitored closely. Patients with moderately decreased or severely impaired kidney or heart function should not use this medication. Especially if kidney function tests reveal values below certain thresholds, use should be discontinued, and the medication should be stopped immediately in suspected cases of kidney dysfunction. Before undergoing tests using radiological iodinated contrast agents, this medication should be discontinued at least 48 hours prior, and re-initiation of use should occur only after confirming normal kidney function post-examination. Women who are pregnant or may become pregnant should preferably avoid this medication. If symptoms such as gastrointestinal disturbances, severe abdominal pain, shortness of breath, skin rash, blisters, etc., occur during use, consult a physician immediately. This medication is also not recommended for patients with poor liver function, and excessive alcohol consumption should be avoided. Elderly patients may experience decreased kidney function; thus, regular kidney function tests are recommended, and dosage adjustments may be needed. Additionally, during administration of this medication, vitamin B12 levels may decrease, so regular blood tests are recommended. In case of overdose, medical help should be sought immediately, as this medication can be removed through hemodialysis. Finally, safety and efficacy have not been established for children, so it is not used in pediatric patients.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with fever, blisters, peeling skin, pain in oral/ocular mucosa, difficulty in breathing or shortness of breath, asthma attacks, breathing difficulties accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme fatigue, sudden and severe headaches, lightning headaches, seizures, altered consciousness, visual disturbances, paralysis, urination issues

Mild side effects

• Hypoglycemia
• constipation
• dizziness
• tremors
• headaches
• weakness
• hunger
• fatigue
• facial swelling
• diarrhea

This medication should be stored in a tightly closed container to protect it from air and moisture. It is recommended to store the medication at room temperature between 1°C and 30°C, avoiding extremely hot or cold places.

Appearance

Yellow, double-convex, oval sustained-release film-coated tablets

Package unit

30 tablets/bottle