Dilatrend SR Tablets 64 mg (Carvedilol)

Adult dose

Administer this medicine orally with food. Do not increase the dose or discontinue treatment without a physician's instructions. Because this is an extended-release formulation, do not take it crushed, powdered, or chewed; swallow the tablet whole. For reference, the daily doses of this medicine (extended-release formulation) corresponding to those of conventional carvedilol formulations are as follows: Daily dose of conventional formulation: 3.125mg twice daily; daily dose of extended-release formulation: 8mg once daily Daily dose of conventional formulation: 6.25mg twice daily; daily dose of extended-release formulation: 16mg once daily Daily dose of conventional formulation: 12.5mg twice daily; daily dose of extended-release formulation: 32mg once daily Daily dose of conventional formulation: 25mg twice daily; daily dose of extended-release formulation: 64mg once daily Daily dose of conventional formulation: 50mg twice daily; daily dose of extended-release formulation: 128mg once daily 1. Essential hypertension Adults: Administer 16mg once daily for 2 days, then increase to 32mg once daily. Usually, administer 32mg once daily for 2 weeks; if the effect is insufficient, the dose may be increased to 64mg once daily. The maximum daily dose of this medicine is 64mg. Older adults: A dose of 16mg once daily may provide sufficient therapeutic effect. If the effect is insufficient after 2 weeks of treatment, the dose may be increased; administer cautiously while monitoring the patient's condition. 2. Chronic stable angina Administer 32mg of carvedilol once daily for the first 2 days, then administer 64mg once daily. Usually, administer 64mg once daily for 2 weeks. If an increase is needed (excluding older adults), administer 128mg once daily. 3. Congestive heart failure For initial treatment, generally administer 8mg of carvedilol once daily for 2 weeks. If the patient tolerates this treatment well, increase the dose to 16mg once daily for 2 weeks, then increase to 32mg once daily for 2 weeks, and then increase to 64mg once daily. Increase the dose gradually after taking each dose for at least 2 weeks, up to the maximum dose tolerated by the patient. The minimum effective dose of this medicine is 16mg once daily. The maximum dose is 64mg once daily in patients weighing 85kg or less, and 128mg once daily in patients weighing 85kg or more.

This medication affects the heart and blood pressure, so it should not be administered to patients with certain heart diseases or severely impaired heart function. It should also be avoided in patients with respiratory diseases such as asthma or chronic obstructive pulmonary disease, as it may worsen symptoms. Patients with diabetes, severely impaired liver or kidney function, and women who are pregnant or nursing should also refrain from taking this medication. Patients should be cautious as symptoms such as dizziness, fatigue, and headache may occur while taking this medication, and there is a risk of heart rate slowing or blood pressure dropping too low. Diabetes patients should frequently check their blood sugar levels, as it may become difficult to control blood glucose levels. If symptoms of liver dysfunction appear (e.g., jaundice, changes in urine color), they should consult a doctor immediately. Stopping this medication suddenly may worsen heart-related symptoms, so the dosage should be gradually reduced under the direction of a physician. It has many interactions with other medications, so it is essential to inform a doctor or pharmacist about any other medications being taken, as this can alter the efficacy of this drug. Elderly patients, children, and patients with certain genetic metabolic traits require careful dosage adjustments and monitoring. Be cautious during activities that require alertness, such as driving or operating machinery, as drowsiness or dizziness may occur. In case of overdose, severe blood pressure drops, cardiac irregularities, and respiratory difficulties may occur, and immediate medical attention should be sought. This medication should be kept out of reach of children and should not be transferred to other containers.

• Dizziness
• headache
• fatigue
• weakness
• hallucinations
• delirium
• depression
• sleep disturbances
• nightmares
• psychosis

This medication should be stored at room temperature between 1°C and 30°C, in a tightly sealed container to prevent air and moisture from entering. Proper storage will help maintain the efficacy of the medication.

Appearance

White oval sustained-release tablet

Package unit

30 tablets/bottle, 100 tablets/bottle