Dapagliflozin/Metformin Extended-Release Tablet 5/1000 mg

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dosage is once daily dapagliflozin 10 mg/extended-release metformin 2000 mg, and 2 tablets of 5 mg/1000 mg are taken. If there is no previous experience with diabetes medication, initial therapy is to take once daily 1 tablet of either 5 mg/500 mg or 10 mg/500 mg. To reduce gastrointestinal side effects of metformin, dosage should be escalated gradually.

This medication is used for the treatment of diabetes and helps control blood sugar. It should not be administered to patients with impaired renal function, severe infections, dehydration, or cardiovascular diseases at the time of prescription. It is also safer for pregnant or breastfeeding women not to use this medication. This medication can rarely cause serious metabolic complications known as lactic acidosis, so it is important to consult a doctor immediately if symptoms occur. Additionally, when taken with insulin or sulfonylureas, there is a risk of hypoglycemia, so care is needed. This medication may increase the risk of infections such as genital infections or urinary tract infections, so treatment should be sought promptly if symptoms of infection appear. Patients with reduced fluid volume or at risk of hypotension should carefully monitor blood pressure and renal function before and after taking this medication. Alcohol consumption should be avoided while taking this medication, and regular testing is recommended as vitamin B12 levels may decrease. If you are undergoing surgery or radiation tests which may affect renal function, this medication should be temporarily suspended and resumed only after checking renal function. Elderly patients or those with diminished renal function need to adjust dosages and regularly monitor kidney function. In case of overdose, prompt assessment and appropriate treatment by medical personnel are necessary, as this medication can be removed through dialysis. Lastly, this medication must be kept out of the reach of children and stored in its original container for safety.

Serious side effects

Lactic acidosis, severe hypoglycemia, severe edema, severe liver abnormalities (jaundice), acute kidney injury, increased blood pressure, diabetic ketoacidosis, perineal necrosis, urosepsis, pyelonephritis, severe allergic reactions (urticaria, severe swelling, chest tightness, breathing difficulties, cold sweats, pallor), severe skin reactions (severe rash with fever, blisters, skin peeling, mucosal pain in mouth/eyes), respiratory issues (shortness of breath or difficulty breathing).

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, dry mouth, dizziness, constipation, back pain, painful urination, polyuria, nocturia, vulvar itching, genital itching, increased hematocrit, decreased early treatment creatinine clearance, dyslipidemia, elevated serum creatinine early in treatment, elevated blood urea, weight loss, Guillain-Barré syndrome, bacterial pneumonia, sialadenitis, tendonitis, and others.

This medication should be stored in a tightly closed container to prevent air or moisture from entering, and it is best kept at room temperature between 1 to 30 degrees Celsius. This storage method helps maintain the medication's effectiveness.

Appearance

A pink, oval, biconvex extended-release film-coated tablet

Package unit

30 tablets/bottle