Metaplex Injection 3%

Adult dosage

Administer intravenously as a drip, with a maximum of 1 to 1.5 g of total amino acids per kg of body weight per day. The infusion rate should aim for a concentration of about 10 g of total amino acids over 60 minutes, with a principle of 80 to 130 drops per minute.

Children's dosage

For children, dosage and infusion rate should be adjusted accordingly.

This medication should only be used according to a physician's instructions. It should not be used in patients with hepatic coma or the risk of hepatic coma, severe renal dysfunction, problems with nitrogen metabolism, congestive heart failure, pulmonary edema, and other specific health conditions. Administration should be avoided if there is hypersensitivity to any of the components or an allergy to specific amino acids. Patients with hyperkalemia or a history of myocardial infarction should also avoid this medication. It should be administered cautiously in patients with severe acidosis, congestive heart failure, edema due to sodium retention, liver or kidney dysfunction. This medication contains sulfites which may cause allergic reactions or asthma attacks in some patients, thus asthmatic patients should be particularly cautious. During use, adverse reactions such as rash, nausea, vomiting, palpitations, and increased blood pressure may occur. If these symptoms arise, administration should be immediately stopped, and consultation with medical personnel is needed. Rapid bulk administration may cause acidosis, hence it is important to administer it slowly. Regular monitoring through tests for blood glucose, electrolytes, liver, and kidney function should be carried out, especially diabetic patients should check their blood glucose levels frequently. This medication may interact with other drugs; caution is particularly recommended when used in conjunction with tetracycline antibiotics or calcium salts. Its safety has not been established in pregnant women, so it should only be used when the therapeutic benefits outweigh the risks. When administering to children, the dosage and infusion rate should be adjusted considering immature liver function, and blood ammonia levels should be tested frequently. Elderly patients may have reduced physical function, thus it is necessary to slow down the administration rate and adjust the dosage accordingly. During administration, care should be taken regarding electrolyte balance, and it should not be infused quickly; the solution should be maintained at body temperature. Preparation of the infusion solution and management of injection devices must be carried out under sterile conditions, and if any abnormalities are found in the solution, it should not be used. For storage, keep unopened packages, do not use if discoloration or leakage is observed, and soft bag products do not require venting, whereas vial products should be vented right before administration.

Serious side effects

• Respiratory distress, respiratory arrest, shock, and bronchospasm may occur along with chills, fever, and headache.
• There is a possibility of severe allergic reactions.
• Asthma attacks can occur in some sensitive patients.

Mild side effects

• Rash may occur rarely.
• Occasionally, nausea and vomiting may arise.
• Chest discomfort, palpitations, tachycardia, and increased blood pressure may occur.
• Chills, fever, and headache may occasionally appear.
• Peripheral vascular dilatation may occur.
• Metabolic acidosis, hypophosphatemia, alkalosis, hyperglycemia, diabetes, osmotic diuresis and dehydration, rebound hypoglycemia, elevated liver enzymes, and vitamin deficiencies and excesses may occur.

This medication should be stored in a sealed container to prevent air ingress, ideally at temperatures between 1 to 30 degrees Celsius. Storing it this way will help maintain the medication's efficacy and safely use it.

Appearance

A colorless or pale yellow transparent solution filled in a colorless transparent polypropylene aqueous injection container.

Package unit

100 milliliters/box, 250 milliliters/box