Wonbufenprimixture Injection (Ibuprofen)

Adult dosage

(1) Adjunct therapy with opioid analgesics (morphine) for moderate to severe pain relief Adults (17 years and older): 400mg-800mg administered intravenously every 6 hours as needed. The maximum daily dose can be up to 3200mg. Administration time should be at least 30 minutes. (2) Antipyretic Adults (17 years and older): 400mg administered intravenously every 4-6 hours as needed. Depending on the patient's condition,

Children's dosage

For fever in children (6 months to less than 17 years): - 6 months to less than 12 years: Starting from 10mg/kg per dose (maximum 400mg), administered intravenously every 4-6 hours as needed, with administration time being

This medication may increase the risk of serious cardiovascular problems such as myocardial infarction and stroke in patients with cardiovascular disease or risk factors. It can cause serious gastrointestinal adverse reactions such as gastrointestinal bleeding, ulcers, and perforation, especially in the elderly or long-term users who need to be more cautious. Patients with a history of gastrointestinal ulcers or bleeding, severe blood, liver, kidney, or heart disease, and those allergic to this medication should not use it. Patients with a history of bronchial asthma or hypersensitivity to aspirin and other non-steroidal anti-inflammatory drugs should not take this medication. In late pregnancy, the risk of premature closure of the ductus arteriosus in the fetus exists, so this medication should not be used. Patients undergoing high-dose methotrexate chemotherapy should also avoid it. Care should be taken when administering this medication to patients with specific conditions such as blood disorders, liver or kidney function impairment, hypertension, heart failure, and especially in the elderly, pregnant, and nursing women. Adverse reactions should be closely monitored during treatment, and if skin rash, breathing difficulties, or severe gastrointestinal symptoms occur, use should be immediately discontinued and medical consultation sought. This medication should not be taken with other non-steroidal anti-inflammatory drugs, and interactions may occur when taken with aspirin, anticoagulants, ACE inhibitors, diuretics, lithium, methotrexate, etc., so patients must inform healthcare professionals of any other medications they are taking. Pregnant women are particularly advised to avoid use after mid-pregnancy, and in nursing women, the medication may pass through breast milk, leading to adverse reactions in the baby; therefore, breastfeeding should be discontinued or medication use avoided. This medication should not be used in children under 6 months of age, as safety and efficacy have not been established, and in the elderly, dose adjustment and monitoring may be necessary due to decreased body function. In cases of overdose, serious symptoms such as dizziness, nausea, vomiting, liver function abnormalities, kidney failure, breathing difficulties, and hypotension may occur, so the dosage must be strictly adhered to, and in cases of overdose, use should be immediately discontinued, and medical treatment sought.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, shedding skin, pain in oral/eye mucosa, difficulty breathing or shortness of breath, asthma attacks, respiratory abnormalities accompanied by cough + fever, jaundice (yellowing of the skin or eyes), profound lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination problems

Mild side effects

• Nausea
• vomiting
• bloating
• headache
• drowsiness
• dyspepsia
• diarrhea
• rash
• itching
• skin reddening

This medication should be stored in a sealed container to prevent contact with air, preferably at a temperature between 1 degree and 30 degrees Celsius (room temperature). Storing it this way helps maintain the effectiveness of the drug and prevents degradation.

Appearance

A colorless or light yellow liquid filled in a colorless transparent plastic container injection.

Package unit

100 milliliters/vial, 200 milliliters/vial