Sitagliptin and Metformin Extended Release Tablets 100/1000 mg (Sitagliptin Hydrochloride Monohydrate, Metformin Hydrochloride)

Adult dose

The dosage of this long-acting tablet is 1 tablet (100/1000 mg) once a day. Patients taking this medication in 50/500 mg or 50/1000 mg formulations should take 2 tablets simultaneously once a day. 1. Patients who are not currently being treated with metformin: The initial dose is a total daily amount of sitagliptin 100 mg and metformin 1000 mg. If the initial dose is insufficient for blood sugar control, adjustments should be made accordingly.

This medication contains sitagliptin and metformin and is used in diabetes treatment. Caution should be exercised for allergic reactions when taking this medication. Severe allergic reactions or skin conditions may occur due to the sitagliptin component; therefore, if such symptoms are suspected, stop taking the medication immediately and consult a doctor. Serious side effects, such as acute pancreatitis (inflammation of the pancreas), have been reported, so if symptoms such as abdominal pain or vomiting occur during use, seek medical attention immediately. The metformin component can very rarely cause life-threatening lactic acidosis, so it should not be taken under conditions of severe dehydration, impaired kidney function, liver disease, or severe infection, and should be discontinued immediately and healthcare professionals notified if symptoms arise. Certain patients, such as those with moderate to severe renal impairment, acute cardiac conditions, or pregnant or breastfeeding women, should not use this medication. Regular kidney function and blood tests should be conducted during treatment, and supplementation may be required if vitamin B12 deficiency occurs. Excessive alcohol consumption should be avoided while taking this medication, and it should be temporarily discontinued prior to surgery or imaging tests involving contrast agents. Additionally, when used with other hypoglycemic agents or insulin, the risk of hypoglycemia may increase, so it is important to watch for symptoms and adjust the dosage according to a doctor's instructions. Care should also be taken in cases of high physical activity or irregular food intake, or when taking other medications concurrently. This medication is not recommended for children under 18 years of age or for pregnant or breastfeeding women. If any abnormal or suspicious symptoms occur during treatment, it is important to consult healthcare professionals immediately.

Serious side effects

Hives, angioedema, anaphylaxis, Stevens-Johnson syndrome, exfoliative skin diseases, acute pancreatitis, acute renal failure, severe hypoglycemia, severe and disabling arthralgia, bullous pemphigoid, elevated liver enzymes, thrombocytopenia, severe edema or urinary abnormalities, lactic acidosis, lactic acidosis due to excessive alcohol intake, severe neurological symptoms (including confusion, seizures, etc.), severe allergic reactions (chest tightness

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infection
• nasopharyngitis
• headache
• muscle pain
• limb pain
• back pain

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture. It is best to maintain a storage temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness safely.

Appearance

Bright blue, oval-shaped, convex extended-release film-coated tablets

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle