Sitagliptin Plus XR Tablet 50/500 mg (Sitagliptin, Metformin)

Adult dose

The 100/1000 mg sustained-release tablet is taken once daily, with 1 tablet at a time. Patients taking the 50/500 mg sustained-release tablet or the 50/1000 mg sustained-release tablet should take 2 tablets at once once daily. 1. For patients not currently treated with metformin: The initial dose is a total daily amount of sitagliptin 100 mg and metformin 1000 mg. Sufficient blood sugar control is required;

This medication contains sitagliptin and metformin and is used for diabetes treatment. First, this medication can cause serious allergic reactions in some patients, so if symptoms such as rash, hives, difficulty breathing, or swelling of the face or neck occur, discontinue use immediately and consult a physician. Additionally, serious side effects such as acute pancreatitis, inflammation of the pancreas, have been reported. If symptoms such as sudden abdominal pain, nausea, vomiting, or fever occur, immediately inform your healthcare provider. This medication should not be used in patients with severely impaired kidney function, acute heart failure, severe infections, dehydration, or in pregnant or breastfeeding women. Patients with impaired kidney function should have regular kidney function tests before and during treatment. If kidney function falls below a certain criterion, the treatment should be discontinued. This medication can also cause a rare but serious metabolic complication called lactic acidosis. Therefore, it should be avoided or discontinued in cases of severe dehydration, hypoxia, liver disease, or severe infections, and if symptoms of lactic acidosis such as weakness, muscle pain, difficulty breathing, or abdominal pain occur, you must seek medical attention immediately. This medication carries a risk of hypoglycemia, so changes in blood sugar should be carefully monitored if meals are skipped, irregular eating habits, vigorous exercise, or when taken with other hypoglycemic agents. If necessary, the physician may adjust the dosage of other medications. Patients who are scheduled for surgery should discontinue this medication 48 hours prior to surgery, and may resume intake only after oral intake has returned to normal and kidney function has been confirmed post-surgery. During the course of taking this medication, you should avoid excessive alcohol consumption as alcohol can increase the risk of lactic acidosis. Furthermore, this medication may interact with certain drugs, so if you are taking any current medications, be sure to inform your doctor or pharmacist. Finally, safety and efficacy in pediatric patients under 18 years of age have not been established, and elderly patients should consider the possibility of decreased kidney function and may require dose adjustments and regular monitoring.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, rash, exfoliative skin disorders (Stevens-Johnson syndrome), acute pancreatitis, acute renal failure, severe and disabling arthralgia, blistering dermatosis, elevated liver enzymes, liver abnormalities (including jaundice), hypoglycemia (severe hypoglycemia), lactic acidosis, acute neurological symptoms (headache, seizures, etc.), severe edema associated with increased blood pressure or urination abnormalities

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• myalgia
• limb pain

This medication should be stored in a tightly closed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius to safely preserve the medication's effectiveness.

Appearance

Light blue, oval-shaped, double convex sustained-release film-coated tablets

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle