Eusitamet XR Extended-Release Tablets 50/1000 mg

Adult dose

The 100/1000 mg extended-release tablets are taken once daily, with one tablet per dose. Patients taking the 50/500 mg extended-release tablets or the 50/1000 mg extended-release tablets should take two tablets together once a day. 1. Patients not currently treated with metformin: The initial dosage is a total daily dose of sitagliptin 100 mg and metformin 1000 mg. If adequate blood sugar control is difficult to achieve

This medication contains sitagliptin and metformin and is used for the treatment of diabetes. Before taking this medication, it is essential to check for any allergic reactions. If symptoms of hypersensitivity such as skin rash, difficulty breathing, or swelling of the face or lips occur, discontinue use immediately and consult a physician. If symptoms of pancreatitis, such as abdominal pain, nausea, or vomiting occur, discontinue the medication and notify healthcare professionals immediately. Patients with severe renal impairment, acute heart failure, severe infections, or dehydration should not use this medication. Before and after tests using iodine contrast agents, this medication should be temporarily discontinued due to the risk of renal function deterioration and lactic acidosis, and it may only be resumed once renal function has been confirmed to be normal. Women who are pregnant or may become pregnant, or who are breastfeeding, should not take this medication. For elderly patients, regular monitoring of renal function is recommended, and starting with the minimum dose is advised. Though rare, lactic acidosis can occur as a serious side effect; thus, if symptoms such as muscle pain, weakness, difficulty breathing, abdominal pain, or abnormal changes in consciousness occur, inform healthcare professionals immediately. Excessive alcohol consumption should be avoided while taking this medication, as alcohol intake may increase the risk of lactic acidosis. Additionally, symptoms of hypoglycemia such as dizziness, tremors, and cold sweats may occur. Therefore, careful monitoring of blood sugar levels is essential, especially when taken with other hypoglycemic agents. If surgery is planned, the medication should be discontinued 48 hours prior to surgery and can be resumed after oral intake has normalized and renal function has recovered. This medication can cause vitamin B12 deficiency; hence, regular blood tests to monitor vitamin B12 levels are necessary for long-term use. Regular monitoring of renal function and hematological tests should be conducted while taking this medication, and any unusual symptoms should be reported to healthcare providers immediately. Finally, this medication is not recommended for children (under 18 years old) as its safety and efficacy have not been established.

Serious side effects

Hives, angioedema, anaphylaxis (severe allergic reaction), rash, Stevens-Johnson syndrome (severe skin reaction), acute pancreatitis, acute renal failure, blistering dermatitis, elevated liver enzymes, thrombocytopenia, rhabdomyolysis, severe hypoglycemia, acute renal failure, liver abnormalities (suspected jaundice), severe allergic reactions, acute pancreatitis, acute deterioration of kidney function, severe neurological symptoms (headache, seizures, altered consciousness, etc.),

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication may be sensitive to air or moisture; therefore, it should be stored in a tightly sealed container. It is also recommended to store it at room temperature between 1 and 30 degrees Celsius. This helps maintain the medication's efficacy over time.

Appearance

Bright green, oval-shaped, biconvex extended-release film-coated tablets

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle