Sitagliptin and Metformin Hydrochloride Extended-Release Tablet 50/500 mg

Adult dose

The dosage of this medication is determined within the limits of the maximum recommended daily dose for each component, which is sitagliptin 100 mg and metformin 2000 mg, considering the patient's current treatment regimen, efficacy, and tolerability. This medication is taken once daily with dinner, gradually increasing the dosage. The extended-release tablet of this medication (100/1000 mg) is taken once daily, 1 tablet each time. This medication (50/500 mg) is

This medication consists of two active ingredients, sitagliptin and metformin, and is primarily used for blood sugar control in patients with type 2 diabetes. First, this medication can rarely cause severe allergic reactions; if allergic symptoms such as skin rash, breathing difficulties, etc. occur, discontinue use immediately and consult your doctor. Second, this medication can induce a serious side effect known as acute pancreatitis, characterized by inflammation of the pancreas, so if symptoms like abdominal pain, vomiting, or loss of appetite occur, immediate medical attention should be sought. Third, the metformin component carries a risk of a rare and potentially life-threatening metabolic disorder called lactic acidosis; therefore, it should not be used in patients with poor kidney function, liver disease, severe infections, or dehydration. Fourth, patients with moderate to severe renal impairment, those with acute heart failure or myocardial infarction, and those undergoing specific tests using iodine contrast agents should not use this medication and must discontinue treatment for a period before and after testing. Fifth, it is safest not to use this medication in pregnant women or those who may become pregnant, nursing mothers, and children under the age of 18. Sixth, this medication may induce hypoglycemia; therefore, patients should carefully monitor blood sugar changes when skipping meals, eating irregularly, engaging in vigorous exercise, or using other hypoglycemic agents concurrently. Seventh, excessive alcohol consumption may increase the risk of side effects from this medication, so it is advisable to avoid drinking while on it. Eighth, during treatment with this medication, regular monitoring of kidney function and blood tests, as well as checking vitamin B12 levels, is recommended. Ninth, if undergoing surgery, medication should be discontinued 48 hours prior to the procedure, and it should only be resumed after normal kidney function has been confirmed post-surgery. Lastly, this medication may interact with other drugs; if you are currently taking other medications, notify your healthcare provider, especially when using drugs that could affect kidney function.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, severe skin reactions (Stevens-Johnson syndrome, rash, cutaneous vasculitis, exfoliative dermatitis), acute pancreatitis, acute renal failure, liver abnormalities (elevated liver enzyme levels, potential for jaundice), severe neurological symptoms (seizures, confusional state, visual disturbances, potential for paralysis), severe hypoglycemia, lactic acidosis, acute heart failure, severe swelling associated with elevated blood pressure, bullous pemphigoid, interstitial nephritis

Mild side effects

Diarrhea, upper respiratory infection, headache, nausea, vomiting, abdominal pain, nasopharyngitis, constipation, muscle pain, limb pain, back pain, pruritus, thrombocytopenia, rhabdomyolysis, hypoglycemia, vitamin B12 depletion, severe joint pain accompanied by disability

Store this medication in a tightly sealed container to avoid exposure to air or moisture, and keep it at a temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain its effectiveness.

Appearance

A bright blue, oval-shaped, convex, extended-release film-coated tablet

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle