Sitagliptin and Metformin Extended-Release Tablet 50/1000 mg (Sitagliptin, Metformin)

Adult dose

The 100/1000 mg extended-release tablet is taken once daily, with one tablet per dose. For patients taking the 50/500 mg extended-release or 50/1000 mg extended-release tablet, take two tablets simultaneously once daily. 1. For patients not currently receiving treatment with metformin: The initial dose is a combined total of sitagliptin 100 mg and metformin 1000 mg per day. If adequate blood

This medication consists of sitagliptin and metformin, which are used in diabetes treatment. First, the sitagliptin component may rarely cause serious allergic reactions. If symptoms such as skin rashes, difficulty in breathing, or swelling of the face or neck occur after taking the medication, discontinue use immediately and consult a doctor. Additionally, sitagliptin may cause acute pancreatitis, so if symptoms such as abdominal pain, vomiting, or nausea occur during treatment, inform your healthcare provider immediately. The metformin component can cause lactic acidosis, a rare side effect that can be very serious and life-threatening. Symptoms of lactic acidosis include severe fatigue, muscle pain, difficulty breathing, abdominal pain, and nausea; if these symptoms occur, discontinue the medication immediately and visit a hospital. This medication should not be administered to patients with moderate to severe renal impairment, those with acute illnesses affecting renal function such as acute heart failure, severe infections, myocardial infarction, or sepsis. If you are scheduled for a procedure using contrast agents, you should discontinue use of this medication for a specified period before and after the examination, and resume only after confirming normal renal function. Women who are pregnant or breastfeeding, children under 18 years, and patients with severe liver dysfunction should also not take this medication. During treatment, be careful as irregular meals, vigorous exercise, and interactions with other medications may increase the risk of hypoglycemia or lactic acidosis. In particular, when taking this medication with insulin or sulfonylurea, the possibility of hypoglycemia increases, so blood glucose levels should be monitored closely. Regular renal function tests and blood tests should be performed, and vitamin B12 levels should also be checked periodically. Excessive alcohol consumption may increase the risk of lactic acidosis, so avoiding alcohol during treatment is advisable. If undergoing surgery, this medication should be temporarily discontinued 48 hours before surgery and resumed only after normal renal function and oral intake have been restored post-surgery. Finally, if any abnormal symptoms appear during the course of treatment, such as joint pain or skin blisters, inform your healthcare provider immediately and seek appropriate measures.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction), severe rash with fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes (severe skin adverse reaction), difficulty breathing or shortness of breath, asthma attack, respiratory issues associated with cough + fever (respiratory problem), yellowing of the skin or eyes (jaundice), extreme fatigue (liver dysfunction), sudden and extreme

Mild side effects

Diarrhea, upper respiratory tract infection, headache, nausea, vomiting, abdominal pain, nasopharyngitis, muscle pain, limb pain, back pain, pruritus, thrombocytopenia, rhabdomyolysis, constipation, decreased vitamin B12 levels in the blood, hypoglycemia, severe joint pain associated with disability

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture. It is best to keep the storage temperature between 1 degree and 30 degrees Celsius.

Appearance

Bright green, oval-shaped, modified-release film-coated tablet with a convex surface on both sides

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle