Amoburofen Primix Injection (Ibuprofen)

Adult dosage

As an adjunct therapy for control of moderate to severe pain with narcotic analgesics (morphine), administer 400 mg to 800 mg intravenously as needed every 6 hours, with a maximum daily dose of 3200 mg. Administration time must be more than 30 minutes. For antipyretic purposes, administer 400 mg intravenously as needed every 4-6 hours. Depending on the patient's condition, after the initial dose of 400 mg, it may be administered every 4 hours.

Children's dosage

For fever in children aged 6 months to under 12 years, administer 10 mg/kg initially (maximum 400 mg) intravenously as needed every 4-6 hours, with a minimum administration time of more than 10 minutes. Maximum per day.

This medication may affect the cardiovascular system; therefore, patients with heart disease or at risk of stroke should consult a doctor before use. Care is particularly needed for those with hypertension or heart failure, or those using it for a long time, as cardiovascular adverse reactions may occur. Serious gastrointestinal side effects such as gastrointestinal bleeding, ulcers, and perforations may occur, so patients with a history of gastrointestinal diseases should avoid its use. Elderly patients or those taking it for a long time are at higher risk of gastrointestinal adverse reactions and should be closely monitored. This medication is contraindicated for certain patients. For example, those with severe liver disorders, renal disorders, severe hypertension, severe heart failure, and those with hypersensitivity to any ingredients in this medication should not take it. Pregnant women in late pregnancy or those with hypersensitivity reactions to aspirin should also avoid its use. Patients with blood disorders or a tendency to bleed, those with impaired liver or kidney function, hypertension, or heart disease should use this medication with caution, and special care is required for pregnant or nursing women and the elderly. While taking this medication, unusual symptoms such as allergic reactions, difficulty breathing, skin rash, severe headache, visual disturbances, and reduced urination may occur, so if any of these symptoms arise, consult a doctor immediately. Do not exceed the recommended dosage, and avoid taking it together with other nonsteroidal anti-inflammatory drugs. Patients with hypertension should frequently monitor their blood pressure at the beginning and during treatment, as fluid retention or edema may occur. Patients with reduced kidney function should be cautious when taking this medication in a dehydrated state, as it may cause kidney damage, and if liver dysfunction is suspected, liver function tests should be conducted. Anemia may occur as observed in blood tests, so blood status should be monitored when taken long-term, and those at risk of bleeding should be cautious as it may affect platelet function. Severe allergic reactions such as anaphylaxis may occur; if symptoms such as difficulty breathing or rash develop after taking, immediate emergency treatment is necessary. This medication should not be taken during pregnancy after 30 weeks, as it may harm the fetus, nor should it be taken by nursing mothers due to the potential transfer of the drug into breast milk. Safety and efficacy have not been established for children under 6 months of age, so it is advisable not to use it for them. Elderly patients may require dosage adjustments and careful monitoring due to decreased bodily function. In cases of overdose, severe symptoms such as dizziness, vomiting, liver dysfunction, kidney failure, or difficulty breathing may occur, and immediate discontinuation and medical treatment are necessary. Finally, there may be interactions with other medications, so patients taking aspirin, anticoagulants, ACE inhibitors, diuretics, lithium, methotrexate, serotonin reuptake inhibitors, etc., should definitely consult with a doctor or pharmacist.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headaches, thunderclap headaches, seizures, confusion, visual abnormalities, paralysis, urinary changes.

Mild side effects

• Nausea
• vomiting
• bloating
• headache
• diarrhea
• indigestion
• abdominal discomfort
• drowsiness
• dizziness
• depression

This medication should be stored at room temperature between 1 to 30 degrees Celsius, in a sealed container to prevent air exposure. This helps maintain the drug's effectiveness for a longer period.

Appearance

An injection filled with a clear colorless to pale yellow liquid in polypropylene and multilayer film plastic containers.

Package unit

104 mL/vial, 208 mL/vial