Hemoshield Hemostatic (Thrombin)

Adult dosage

Dissolve thrombin freeze-dried powder 5000 units in normal saline to prepare a thrombin solution of 50–1,000 units/mL. Typically sprayed, applied, or distributed as powder over the site of local bleeding, adjusting as appropriate according to the site and degree of bleeding. The collagen-based tissue filler should be injected evenly after thoroughly disinfecting the application area and removing the cap from the prefilled syringe to attach to a commercial injection needle.

This drug is made with thrombin, which helps blood clotting. It must not be administered by injection under any circumstances. If used locally in solution form, extreme caution should be exercised to prevent it from entering the bloodstream. Entry into the bloodstream can cause serious life-threatening complications due to clotting. Additionally, this drug may cause allergic reactions, so patients with a history of allergies to this drug or components derived from cows should not use it. Patients with severely impaired liver function or bleeding disorders, as well as pregnant women or those who might become pregnant, should exercise particular caution when using this drug. Rarely, serious allergic reactions such as respiratory distress or hypotension may occur, so if symptoms appear, use must be discontinued immediately and appropriate treatment sought. The risk of thrombosis increases when used with other clotting-related medications, so it must be discussed with a physician. Safety for pregnant women and children has not been established, so it should be used cautiously. This drug should be used immediately after preparation, and when stored, it should be protected from acidic or alkaline environments, heat, heavy metals, and so on. Furthermore, the collagen-based tissue filler used alongside this drug should not be used in patients with allergies to porcine proteins or with infectious diseases. When using the tissue filler, ensure sterility to reduce the risk of infection, and do not reuse any leftover product and must discard it properly. If swelling or warmth is present at the treatment site, care should be taken to avoid exposure to extreme temperature changes, and if side effects persist or worsen, medical consultation is necessary.

Serious side effects

• Hives
• severe swelling (edema)
• respiratory distress
• hypotension
• severe allergic reactions
• shock
• coagulation abnormalities
• unusual bleeding
• severe edema or urinary abnormalities
• severe thrombosis

Mild side effects

Rash, fever, itching, swelling, nausea, vomiting, headache, inflammatory reactions accompanied by itching and pressure-related pain, swelling, erythema, localized swelling, rash and other immune responses, bleeding, hematoma, skin changes, lump formation, persistent pain, fractures, bone resorption, delayed bone union, non-union of bone, articular syndrome

This drug should be stored in a sealed container to prevent exposure to air and should be kept at room temperature between 1 degree and 30 degrees Celsius. Storing it this way maintains the drug's effectiveness.

Appearance

A kit consisting of BM Thrombin freeze-dried powder 5000 units (Thrombin) (one vial of each drug and diluent) and collagen-based tissue filler.

Package unit

1 kit/kit