Tenegliptin M Sustained Release Tablet 10/500 mg

Adult dose

Typically, this medication is administered once daily with the evening meal, and the dosage is titrated gradually to minimize gastrointestinal side effects associated with metformin. The sustained-release tablets of this medication 20/1000 mg are taken once daily, one tablet at a time. Patients taking this medication 10/750 mg or 10/500 mg sustained-release tablets are to take two tablets at the same time once daily. In patients who are unable to achieve adequate blood glucose control with metformin monotherapy, the initial dosage of this medication should provide teneligliptin 20 mg once daily along with the current metformin dose. For patients switching from a combination therapy of teneligliptin and metformin to this medication, the dose can start at the existing doses of teneligliptin and metformin. When switching from immediate-release metformin to the sustained-release formulation, blood glucose control should be closely monitored, and dosage adjustments should be made appropriately. When co-administering with sulfonylureas, consideration should be given to reducing the dosage of sulfonylureas to decrease the risk of hypoglycemia. The maximum recommended daily dosage is teneligliptin 20 mg and sustained-release metformin 2000 mg. The safety and efficacy of this medication have not been specifically evaluated in patients switching from other antidiabetic medications to this medication. Any changes in the treatment of patients with type 2 diabetes must be closely monitored due to the potential for affecting blood glucose control. To maintain the sustained-release characteristics, this medication should be swallowed whole and not split, crushed, or chewed.

This medication can very rarely cause a severe side effect known as lactic acidosis; if symptoms occur, you should seek medical attention immediately. Patients with moderate to severe renal impairment, heart issues, acute infections, or serious trauma should not use this medication. It is essential to discontinue this medication before undergoing tests that use radiologic iodine contrast agents, and resume only after confirming normal kidney function. This medication can induce hypoglycemia; therefore, when used in conjunction with insulin or other antidiabetic medications, be cautious of hypoglycemic symptoms and consume sugar immediately if symptoms appear. Patients with severe liver or lung impairment, persons who consume excessive alcohol, and those in poor nutritional status should use this medication with caution. Pregnant women or those who may become pregnant should not take this medication, and breastfeeding women should consult a doctor before using it. Elderly patients may experience reduced kidney function, so regular kidney function tests should be conducted, and dosage adjusted accordingly. It is advisable to avoid alcohol consumption while taking this medication, and if sudden vomiting, diarrhea, or dehydration occurs during treatment, consult healthcare professionals immediately. This medication may interact with specific drugs, so if you are taking other medications, be sure to inform your doctor or pharmacist. If severe abdominal pain, vomiting, skin rash, or shortness of breath occurs while taking this medication, seek medical attention immediately. Since the safety and efficacy of this medication have not been established in children, it is recommended not to use it in that population.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, skin peeling, pain in oral/eye mucosa, difficulty breathing or shortness of breath, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), severe lethargy, sudden and severe headaches, lightning-like headaches, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

• Hypoglycemia
• constipation
• dizziness
• tremors
• headaches
• weakness
• hunger
• fatigue
• facial swelling
• diarrhea

This medication should be stored in a closed container to prevent air from entering and kept at a temperature between 1 degree and 30 degrees Celsius. Storing it this way will help maintain the medication's effectiveness and prevent deterioration.

Appearance

Orange oval-shaped sustained-release film-coated tablet

Package unit

30 tablets/bottle