Zadiwon Duo Tablet 5/1000 mg

Adult dose

The recommended dosage of this medicine is 1 tablet once, two times a day. Dosage should be determined considering each patient's current treatment regimen, efficacy, and tolerability, not exceeding a total daily dose of 25 mg of empagliflozin and 2000 mg of metformin. For patients where blood sugar control is insufficient with metformin alone or in the case of combination therapy with insulin, the recommended dose is 5 mg of empagliflozin twice daily (total 10 mg) along with the existing dose of metformin.

This medicine helps to control blood sugar levels. However, there's a risk of developing a rare side effect called severe lactic acidosis, so caution is needed. When taken with other hypoglycemic agents, there is a risk of hypoglycemia, which should be approached carefully. It should not be administered to patients with significantly impaired kidney function, acute kidney problems, heart failure, or diabetic ketoacidosis. It is necessary to temporarily suspend use of this medicine before and after using iodine contrast agents and to resume only after normal kidney function has been confirmed. It is safe not to use this medicine during pregnancy or breastfeeding. Regular kidney function checks are required while taking this medicine, and immediate consultation with a doctor is needed if symptoms of dehydration or severe infections occur. Symptoms of hypoglycemia may appear, so especially when taking with insulin or sulfonylurea drugs, blood sugar levels should be monitored carefully. Urinary tract infections or genital infections may occur, so prompt treatment should be received if symptoms of infection appear. Vitamin B12 levels may decrease, so it is advisable to check vitamin B12 status during long-term use. Excessive alcohol consumption may increase the risk of side effects from this medicine, thus it should be avoided. Elderly patients or those with weakened kidney function should take special care, and dose adjustment may be necessary. If surgery is planned, this medicine should be stopped 48 hours prior to surgery and resumed only after kidney function has returned to normal. An overdose may lead to severe side effects such as lactic acidosis, and immediate medical treatment is required. This medicine is not recommended for children, and when storing the medication, it should be kept out of reach of children.

Serious side effects

• Hives
• severe swelling (edema)
• lactic acidosis
• ketoacidosis
• vascular edema
• severe allergic reaction
• severe skin adverse reactions
• difficulty breathing
• respiratory distress
• asthma attack

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medicine should be stored in a tightly closed container to avoid exposure to air or moisture, and it is advisable to keep it at room temperature between 1 and 30 degrees Celsius. Proper temperature and storage can maintain the effectiveness of the medicine and prevent deterioration.

Appearance

Yellow, biconvex, oval film-coated tablet with a brown tint

Package unit

60 tablets/bottle, 30 tablets/bottle, 60 tablets/box [(10 tablets/PTP x 6)], 10 tablets/box [(10 tablets/PTP x 1)]