Enpyang Duo Tablet 5/850 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dose of this medication is 1 tablet once daily, administered twice a day. Dosing is determined based on each patient’s current therapeutic regimen, efficacy, and tolerability, ensuring that Empagliflozin does not exceed 25 mg and Metformin does not exceed 2000 mg. For patients who cannot achieve adequate blood sugar control with Metformin alone or in combination with insulin or other medications, the recommended dose is Empagliflozin 5 mg twice daily (total daily dose of 10 mg) alongside their current Metformin regimen.

This medication is used to lower blood sugar and is particularly helpful in diabetes treatment. It can cause a rare but fatal side effect known as severe lactic acidosis, thus should not be used in patients with impaired kidney function or certain diseases. Additionally, caution is needed when used alongside insulin or other diabetes medications as hypoglycemic symptoms may occur. Patients with impaired kidney function, acute infections or dehydration, and acute heart conditions should not take this medication as it can pose risks. During treatment with this medication, regular blood tests should be performed to monitor kidney function and blood sugar status, especially for the elderly or those with impaired kidney function. Side effects such as gastrointestinal disturbance, urinary tract infections, genital infections, increased urination, and hypoglycemia may occur; if symptoms are severe, consult a doctor. This medication should be temporarily discontinued before and after surgeries or procedures using radiocontrast agents until kidney function is restored. Pregnant or breastfeeding women should not take this medication, and particularly women who may become pregnant should consult a doctor before use. Alcohol consumption can increase the risk of lactic acidosis, so it is advisable to avoid drinking while on this medication. When administering this medication to the elderly, kidney function should be closely monitored, and dose adjustments made as necessary. In case of overdose, serious issues such as lactic acidosis may occur, so it is important to take the prescribed dose as directed by a doctor. Lastly, keep this medication out of reach of children and store it in its original container to maintain quality.

Serious side effects

Hives, angioedema, necrosis of the perineum, ketoacidosis, lactic acidosis, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme drowsiness, sudden and severe headache, thunderclap headache, seizures, confusion, vision changes, paralysis, significantly reduced urine output, severe malaise.

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It is best kept at room temperatures between 1°C and 30°C, avoiding extremely hot or cold places.

Appearance

White, oval, double convex film-coated tablet with a yellowish tint

Package unit

10 tablets/box[(10/PTP X 1)], 60 tablets/box[(10/PTP X 6)], 30 tablets/bottle, 60 tablets/bottle