Empacombi Tablet 5/850 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage of this medication is 1 tablet per dose, 2 times a day. The maximum recommended daily dose of empagliflozin is 25 mg, and the maximum recommended daily dose of metformin should not exceed 2000 mg, and should be adjusted based on each patient's condition. - For patients who have difficulty achieving sufficient blood sugar control with metformin alone or in combination with other medications such as insulin, the recommended dosage is 5 mg of empagliflozin 2 times a day (total of 10 m

This drug is used for the treatment of diabetes, with the active ingredients empagliflozin and metformin hydrochloride working to lower blood sugar. Caution is required when taking this medication, as a rare side effect known as severe lactic acidosis may occur. Lactic acidosis is a condition where lactic acid accumulates excessively in the blood, posing harm to the body and potentially life-threatening in severe cases. Additionally, when used in conjunction with insulin or sulfonylurea drugs, hypoglycemia, or abnormally low blood sugar levels, may rarely occur, so caution is advised. This medication should not be administered to patients with moderately to severely impaired renal function or those experiencing acute kidney issues, severe infections, heart failure, or acute myocardial infarction. When undergoing tests that use iodinated contrast agents, the medication should be discontinued for a certain period before and after the examination, and it should only be resumed once normal renal function is confirmed. It is safer not to use this medication in pregnant women or those who may become pregnant, as well as nursing mothers. Patients should be cautious of fluid loss and dehydration symptoms while taking this medication, particularly elderly patients or those with cardiovascular disease, who should take extra care. This drug can reduce vitamin B12 levels, so it is advisable to check vitamin B12 status during long-term use. There is a risk of hypoglycemia; therefore, missing meals, irregular eating, excessive exercise, or alcohol consumption should be approached cautiously. This medication may increase the risk of urinary and genital infections; if any infection symptoms occur, immediate consultation with healthcare professionals is necessary. Patients planning for surgery should discontinue this medication 48 hours prior and resume it only after confirming normal renal function following the procedure. In cases of overdose, the risk of lactic acidosis may increase significantly; therefore, immediate medical treatment is required, and hemodialysis may be necessary. Regular monitoring of blood sugar and renal function should occur during the use of this medication, and any unusual symptoms should be reported to healthcare providers promptly. The safety and effectiveness of this medication have not been established in children, so it should not be used in this population.

Serious side effects

• Urticaria
• angioedema
• urinary sepsis
• pyelonephritis
• perineal necrosis
• ketoacidosis
• lactic acidosis
• acute kidney injury
• hepatitis
• myocardial infarction

Mild side effects

• Hypoglycemia
• urinary tract infections
• genital infections
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a tightly sealed container to protect it from exposure to air and moisture. It is important to maintain storage temperatures between 1 to 30 degrees Celsius at room temperature to extend the medication's effectiveness.

Appearance

White, oval-shaped, biconvex film-coated tablet with a yellow tint

Package unit

10 tablets/box [(10 tablets/PTP x 1)], 60 tablets/box [(10 tablets/PTP x 6)], 30 tablets/bottle, 60 tablets/bottle