Tenetin M Controlled-release Tablet 10/750 mg

Adult dose

This medication is typically administered once daily with the evening meal. The 20/1000 mg controlled-release tablet is taken once daily, at a dose of one tablet. Patients taking the 10/750 mg or 10/500 mg controlled-release tablet should take two tablets simultaneously once daily. For patients who cannot achieve adequate blood sugar control with metformin alone, the initial dose is teneligliptin 20 mg once daily combined with metformin.

This medication is used for diabetes treatment and has the effect of lowering blood sugar. However, it may rarely cause a serious metabolic complication known as lactic acidosis, requiring caution. Lactic acidosis is particularly dangerous in patients with decreased kidney function, heart disease, sepsis, etc. This medication should not be administered to patients with moderate to severe renal impairment or severe heart failure. Additionally, this medication should be temporarily discontinued before and after tests using radiologic contrast agents and restarted only after confirming normal kidney function. It is also safe not to use this medication during pregnancy or for women who may become pregnant, patients with significantly impaired liver function, severe infections, or trauma. This medication may increase the risk of hypoglycemia when combined with other diabetes medications, so it is essential to be aware of hypoglycemia symptoms and management methods. Patients should regularly monitor kidney and liver functions and check vitamin B12 levels regularly during treatment. If sudden abdominal pain, vomiting, difficulty breathing, muscle pain, or fatigue occurs during use, consult a doctor immediately. The risk of lactic acidosis increases when taken with alcohol; therefore, it is advisable to avoid alcoholic beverages. Elderly patients or those with compromised kidney function particularly require dosage adjustments and regular monitoring. Patients about to undergo surgery should discontinue this medication 48 hours before surgery and restart it only after confirming normal kidney function post-surgery. This medication has not been proven safe and effective in children or adolescents, so it should not be used in these populations. Moreover, while taking this medication, if severe joint pain or skin blisters occur, inform healthcare personnel immediately. Store this medication out of the reach of children, and be cautious as transferring it to another container may alter its quality.

Serious side effects

Hypoglycemia, lactic acidosis, intestinal obstruction, liver dysfunction, interstitial pneumonia, vesicular-like pemphigoid, acute pancreatitis, severe joint pain, severe allergic reactions (hives, significant swelling, chest tightness, difficulty breathing, cold sweats, pallor), severe skin adverse reactions (severe rash with fever, blisters, skin peeling, oral/eye mucosal pain), respiratory issues (shortness of breath or difficulty breathing, asthma attacks, cough with fever

Mild side effects

• Dizziness
• constipation
• abdominal distention
• abdominal discomfort
• nausea
• abdominal pain
• bloating
• stomatitis
• gastric polyps
• colonic polyps

This medication should be stored in a tightly sealed container to prevent air ingress and kept at room temperature between 1 degree and 30 degrees Celsius. Proper storage maintains the efficacy of the medication and prevents degradation.

Appearance

Yellow, egg-shaped controlled-release film-coated tablet

Package unit

Bottle - 30 tablets/bottle