Tenelipone Sustained Release Tablet 10/500 mg

Adult dose

This medicine is generally administered once daily with the evening meal. The 20/1000 mg sustained release tablet is taken once daily, one tablet per dose. The 10/750 mg or 10/500 mg sustained release tablet is taken once daily, two tablets at the same time. The maximum recommended daily dosage is 20 mg of teneligliptin and 2000 mg of sustained release metformin. To maintain its sustained release properties, this medicine should not be split, crushed, or chewed.

This medicine can rarely cause a serious condition called lactic acidosis. Lactic acidosis is a dangerous condition caused by excessive accumulation of lactic acid in the body, which can be life-threatening if not treated. During the use of this medicine, hypoglycemia may occur, so extra caution is needed, especially when taken with insulin or sulfonylurea drugs. If symptoms of hypoglycemia appear, it is important to immediately consume food that contains sugar. This medicine is not to be administered to patients whose renal function is moderately impaired or worse, or who have serious conditions such as heart failure, acute myocardial infarction, or sepsis. Additionally, if iodine-based contrast agents used in radiological examinations are administered, this medicine should be discontinued 48 hours prior to the examination and resumed only after confirming normal kidney function. It is also unsafe for women who are pregnant or may become pregnant, patients with liver dysfunction, patients with severe infections or traumatic conditions, and patients with very poor nutritional status to use this medicine. Due to the risk of hypoglycemia, patients with irregular meal patterns or insufficient meal quantities, those who engage in vigorous exercise, or those taking sulfonylurea or insulin should be particularly cautious. Regular checks of liver and kidney functions should be performed during the use of this medicine, and if any unusual symptoms such as gastrointestinal disturbances, liver dysfunction, acute pancreatitis, or skin rashes appear, one should immediately consult a physician. Alcohol consumption may increase the risk of lactic acidosis, so it is advisable to avoid drinking while taking this medicine. Elderly patients are more prone to renal function decline, thus dosage adjustment and regular monitoring of renal function is necessary. If breastfeeding, the use of this medicine is not recommended, and one should consult a doctor whether to continue breastfeeding or discontinue medication. In case of overdose, one should immediately visit a medical institution for appropriate treatment, and the drug can be removed through hemodialysis. This medicine should be stored out of reach of children and should not be transferred to another container. During the use of this medicine, one should be well aware of the symptoms of hypoglycemia and lactic acidosis, and in case of any suspected symptoms, immediately inform healthcare providers.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with fever, blisters, peeling skin, pain in oral/ocular mucous membranes, shortness of breath or difficulty in breathing, asthma attack, respiratory disturbances accompanied by coughing and fever, jaundice, extreme fatigue, sudden and severe headache, lightning headache, seizures, confusion, visual disturbances, paralysis, urine retention

Mild side effects

Hypoglycemia, constipation, dizziness, trembling, headache, weakness, hunger, fatigue, facial swelling, diarrhea, indigestion, nausea, itching, diabetic retinopathy, vision loss, cough, pulmonary congestion, drug overdose, benign prostatic hyperplasia, upper abdominal pain, gastritis, viral upper respiratory infection, shingles, limb pain, nasopharyngitis, bone fracture, nausea/vomiting, decreased serum vitamin B12 concentration, lethargy, allergic rhinitis, elevated serum uric acid

This medicine should be stored in a tightly sealed container to prevent air from entering, and it is best to store it at room temperature between 1°C and 30°C. Storing it this way helps to maintain the efficacy of the medication for a longer time.

Appearance

Orange egg-shaped sustained release film-coated tablet

Package unit

30 tablets/bottle