Zepogajeong 10 mg (Dapagliflozin Propanediol Hydrate)

Adult dose

The recommended dosage of this medication is 10 mg once daily for monotherapy and as an adjunct in combination with other hypoglycemic agents, including insulin. When this medication is used in conjunction with insulin or secretagogues such as sulfonylureas, lower doses of insulin or secretagogues may be considered to reduce the risk of hypoglycemia. In cases where there has been no prior treatment with diabetes medications, metformin may be used.

Child dose

The efficacy and safety of dapagliflozin in children under 18 years of age have not been established. There is no related data.

This medication should not be administered to certain patients. It should not be used in patients who are allergic to the active ingredients or excipients, patients with type 1 diabetes or diabetic ketoacidosis, those with genetic lactose intolerance issues, and patients who are undergoing dialysis. It should be used cautiously in patients with reduced fluid volume or kidney dysfunction, and fluid status and kidney function should be assessed before administration. After administration, symptoms of hypotension and kidney function should be monitored periodically. This medication is not recommended for patients with severely reduced kidney function. In clinical trials and post-marketing studies, the most common side effect has been genital infections, which may occur more frequently in women or patients with a history of infections. Hypoglycemia may occur primarily when used in combination with insulin or sulfonylureas; thus, dosage adjustment of insulin or secretagogues may be necessary to reduce the risk of hypoglycemia. Symptoms of dehydration or hypotension due to reduced fluid volume may occur; immediate consultation with healthcare personnel is required if such symptoms arise. Diabetic ketoacidosis can occur even when blood sugar levels are not high; symptoms such as nausea, vomiting, abdominal pain, and difficulty breathing require immediate investigation and treatment. There is an increased risk of urinary tract infections and pyelonephritis; rapid treatment is necessary if signs of infection occur. There is limited experience using this medication in patients with severely impaired liver function, so caution is required. It is recommended that women who are pregnant or breastfeeding do not use this medication, and administration should be discontinued if pregnancy is confirmed. Elderly patients should have careful monitoring of kidney function and fluid status. During the course of this medication, glucose may be detected in urine tests, which should be taken into account when evaluating blood sugar control. There is no specific antidote for overdose; appropriate treatment should be administered according to symptoms. Finally, while this medication does not significantly impact the ability to drive or operate machinery, caution is needed due to the risk of hypoglycemia when used in combination with insulin and others.

Serious side effects

Rash, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough + fever, yellowing of skin or eyes (jaundice), profound lethargy, sudden and severe headache, lightning headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

Vulvitis, glansitis, and related genital infections, urinary tract infections, fungal infections, hypoglycemia, dry mouth, dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, increased hematocrit, reduced creatinine clearance at the start of treatment, dyslipidemia, elevated blood creatinine, elevated blood urea, weight loss, dyspepsia, nausea, diarrhea, vomiting, itching, rash, sweating, headache, fatigue, hunger, vaginal discharge

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture. It is important to maintain storage temperatures between 1 degree and 30 degrees Celsius. Proper storage will ensure that the medication's effectiveness and safety are maintained for an extended period.

Appearance

Yellow, biconvex, diamond-shaped film-coated tablets

Package unit

28 tablets (14 tablets/PTP × 2)